教育经历

2003-2007 湖南大学  生命科学与技术学院 学士

2007-2013 清华大学  生命科学学院     博士

工作经历与任职

2013-2015 清华大学            博士

2015-2019 美国加州大学圣地亚哥分校　博士后及助理项目科学家

2019-至今 武汉大学医学研究院　　　　教授

所获研究资助

国家自然科学基金面上项目（2021-2024，主持）

武汉大学双一流建设专项人才启动经费（2020-2022，主持）

国家自然科学基金青年科学基金项目 （2014-2016，主持）

研究领域

　　本课题组主要从事细胞自噬的分子机制及其与人类疾病关系的研究。运用酵母，哺乳动物细胞和果蝇为模型；细胞生物学、分子生物学、生物化学及遗传学手段来研究细胞自噬（主要是内质网选择性自噬）的分子机制，及其与人类疾病（主要是神经退行性疾病）的关系。

代表性论文

[1] Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, and Susan Ferro-Novick*. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science, 365, 53 –60, 2019 (Article, IF2019 =41, first author);

[2] Yixian Cui, Smriti Parashar, and Susan Ferro-Novick*. A new role for a COPII cargo adaptor in autophagy. Autophagy, Dec 3:1-3, 2019 (Commentary, IF2019 =11, first author);

[3] Shuliang Chen, Yixian Cui, Smriti Parashar, Peter J. Novick*, and SusanFerro-Novick*. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 115(27), E6237-E6244, 2018 (Article, IF2019=9.6, second author);

[4] Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick*, Susan Ferro-Novick*. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A 117(31), 18530-18539, 2020 (Article, IF2020=9.4, co-author);

[5] Yixian Cui* Shanke Zhao, Xudong Wang, Bing Zhou*. A novel Drosophila mitochondrial carrier protein acts as a Mg2+ exporter in fine-tuning mitochondrial Mg2+ homeostasis. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1863, 30–39, 2016 (Article, IF2019=4.7, co-first author and co-corresponding author);

[6] Yixian Cui*, Shanke Zhao, Juan Wang, Xudong Wang, Bingquan Gao, Qiangwang Fan, Fei Sun, Bing Zhou*. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1853, 724–732, 2015 (Article, IF2019=4.7, co-first author and co-corresponding author);

[7] Yixian Cui, Shanke Zhao, Zhihao Wu, Pinghua Dai, Bing Zhou*. Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast. Molecular Biology of the Cell 23, 22, 4373-4382, 2012 (Article, IF2019=3.9, first author).

 课题组热情欢迎对科研有兴趣的博士后、博士研究生、硕士研究生及本科生加盟。