科学研究
20171001 Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells
发布时间:2017-10-01  来源:  阅读次数:
2017 Oct;183:145-157. doi: 10.1016/j.clim.2017.08.012. Epub  2017 Aug 26.

Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells.

Ding Q 1, Shen Y 1, Li D 2, Yang J 1, Yu J 3, Yin Z 4, Zhang XL 5.

Abstract

Ficolin-2 is an important serum complement lectin. Here, we describe novel findings indicating that serum ficolin-2 concentrations in multiple tumor patients are significantly lower than those in healthy donors. Administration of exogenous ficolin-2 or ficolin-A (a ficolin-2-like molecule in mouse), with only once, could remarkably inhibit the tumor cells growth in murine tumor models via early macrophages, dendritic cells (DCs) and CD8+ T cells, but not CD4+ T cells. Ficolin-A (FCN-A) knockout (KO) mice exhibits significantly increased tumor cell growth. Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8+ T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8+ T cells. Our findings provide a new therapeutic strategy for tumors based on the triggering of immune-mediated antitumor effect by ficolin-2.

KEYWORDS:

Antitumor effect; CD8(+) T; Dendritic cells (DCs); Ficolin-2/A; Macrophage


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