Bo Zhong-医学研究院
Bo Zhong
Author:  Date:2015-12-01  Clicks:

Professor, Principle Investigator

College of Life Sciences, State Key Laboratory of Virology

Medical Research Institute, Wuhan University

Wuhan, China, 430072

Tel: 86-27-68752202

Fax: 86-27-68752246

Email: zhongbo@whu.edu.cn

 

Bo Zhong, PhD 

 

Research Area

Innate antiviral immunity, Inflammation and tumorigenesis

 

Education

2001.92005.6 B.A. in English

Foreign Languages Department

China University of Geosciences, Wuhan, China

2003.22005.6 B.S. in Biology

College of Life Sciences

Wuhan University, Wuhan, China

2005.92010.6 Ph.D in Cell and Developmental Biology

College of Life Sciences

Wuhan University, Wuhan, China

 

Employment

2010.72013.5 Postdoctoral Fellow

Department of Immunology

Center for Inflammation and Cancer

The University of Texas

MD Anderson Cancer Center, Houston, TX

2013.3now Professor

College of Life Sciences

State Key Laboratory of Virology

Medical Research Institute

Wuhan University, Wuhan, China

 

Awards and Honors

2015 One of Ten Excellent Young Faculties of Wuhan University, China

2014 One Thousand Youth Talents Project, China

2012 National Excellent Doctoral Dissertation, Ministry of Education, China

2012 Abstract Award, American Association of Immunologists, USA

2011 Odyssey Fellowship, MD Anderson Cancer Center

2010 Invited to the 60th Lindau Nobel Laureates Meeting, Germany

2009 The Ray Wu Prize Fellow, The Ray Wu Memorial Fund, USA (http://www.raywumemorialfund.org/2009winner.php)

 

Research Interest

Protein ubiquitination and deubiquitination plays diverse roles in signaling transduction, development, immunity and inflammation. Dr. Zhong’s lab works on ubiquitination and deubiqutination process during innate antiviral immune and inflammatory responses and tumorigenesis. His lab focuses on E3 ligases and deubiquitinases that regulate virus-triggered immune signaling and elucidates the mechanisms with gene-knockout mice and the related disease models.

 

Publications

1.      Lin D, Zhang M, Zhang MX, Ren YJ, Zhao Q, Jin J, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329. (* corresponding author)

2.      Wei J, Lian H, Zhong B, Shu HB. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1. J Immunol. 2015 195(6):2870-8.

3.      Deng T, Lin D, Zhang M, Zhao Q, Li W, Zhong B, Deng Y, Fu X. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma. Acta Biochim Biophys Sin. 2015 47(7):557-63.

4.      Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155. (* corresponding author)

5.      Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014, 507(7493):513-8.

6.      Luo WW, Lian H, Zhong B, Shu HB, Li S. Krüppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol. 2014 Dec 22.

7.      Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB, Wang YY. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 2014, 16(4):450-6.

8.      Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L, Zhong B, Shu HB. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 2014, 10(9):e1004358.

9.      Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses. J Innate Immun. 2015, 7(2):153-64.

10.  Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes. J Biol Chem. 2014, 289(18):12876-85.

11.  Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014, 111(4):1509-14.

12.  Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013). J Biol Chem. 288, 12596-604.

13.  Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C. Ubiquitin-specific Protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013). Sci Signal. 6, ra35.

14.  Liu XK#, Li HX#, Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013). J Exp Med. 210, 1575-90. (#Co-first authors)

15.  Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012). Nat Immunol. 13, 1110-17.

16.  Liu XD, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. (2012). J Exp Med. 209:1841-52.

17.  Xu T#, Wang X#, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011). J Biol Chem. 286, 22707-10.

18.  Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S and Shu HB. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010). Immunity. 33, 878-89.

19.  Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010). J Immunol. 184, 6249-6255.

20.  Zhong B, Wang YY and Shu HB. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010). Frontier in Biology 5, 12-31.

21.  Zhong B, Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009). Immunity 30, 397-407.

22.  Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008). Immunity 29, 538–550.

23.  Zhong B, Tien P and Shu HB. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006). Virology 352, 14-21.

24.  Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. (2010). Proc Natl Acad Sci U S A. 107, 815-820.

25.  Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q and Shu HB. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN- and cellular antiviral response. (2010). J Biol Chem. 285, 9470-9476.

26.  Chen R, Zhang L, Zhong B, Tan B, Liu Y and Shu HB. Ubiquitin-specific protease 17 is involved in virus-triggered type I interferon signaling. (2010). Cell Res. 20: 802-11. 

27.  Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010). J Biol Chem. 285, 4291-4297.

28.  Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. (2009). Proc Natl Acad Sci U S A. 106, 7945-50.

29.  Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z, Zhong B, Tien P and Shu HB. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxya. (2007). Proc Natl Acad Sci U S A. 104, 11706-11711.

30.  Tian Y#, Zhang Y#, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007). J Biol Chem. 282, 16776-11782. (#Co-first authors).

31.  张煜,钟波,杨艳,舒红兵. TLRsRLRs介导的细胞抗病毒反应信号转导及其调节机制. (2009). 细胞生物学杂志 31, 453-468.

32.  钟波舒红兵. 天然免疫模式识别受体与树突状细胞的发现和意义——2011年诺贝尔生理学或医学奖成果和相关研究. 生命科学 (2011). 23, 1147-1161.

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