Hao-Jian Zhang
Professor, Medical Research Institute, Wuhan University

Hao-Jian Zhang, PhD



2008-2012Ph.D.University of Massachusetts Medical School, USA

2006-2008 The Jackson Laboratory, USA

2001-2004M.S.Institute of Zoology, Chinese Academy of Sciences, China

1997-2001B.S.College of Life Science, Shandong Normal University, China


Professional Experience:

2016--presentProfessorMedical Research Institute, Wuhan University

2012--2016 Research FellowDana Farber Cancer Institute, Harvard Medical School

2012 Postdoctoral AssociateUniversity of Massachusetts Medical School

2004--2006 Research ScientistNeuropharmacology Division, Shanghai Institute of

Materia Medica,Chinese Academy of Sciences


Scholarships and Awards

2016 Harvard Chinese Life Science YongJin Annual Distinguished Research Award

2015 “1000 Young-Talented program”

2013-2016 Leukemia Lymphoma Society Fellow Award

2010 American Society of Hematology Annual Meeting Travel Award

2006-2008 “GSBS” Fellowship, The Jackson Laboratory



1.Zhang H,Kozono D, O’Connor K, Vidal-Cardenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano E, Greenberger J, Bagby G, Soulier J, Grompe M, Parmar K, D’Andrea A (2016). TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia.Cell Stem Cell18, 1-14.

2.Zhang H,Peng C, Zhi S, Hu Y, Li H, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Li D, Green M, Li S (2012). The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.Nature Genetics44 (8): 861-871.

3.Zhang H*, Li S(2016).Induction of chronic myeloid leukemia in mice.Methods Mol. Bio.In Press.(*Corresponding author)

4.Zhang H*,Li S, Li H (2014). Management andorphan drugs development for acute myeloid leukemia.Expert Opinion on Orphan Drugs. 5:441-451.(*Corresponding author)

5.Zhang H,Li S (2013).Molecular Mechanisms for survival regulation of chronic myeloid leukemia stem cells.Protein Cell. 4:186-196.

6.Yang Z,Zhang H, Ma L,Peng C, Chen Y, Wang J,Green M,Li S, Rosmarin A (2013). Transcriptional factor GABP is required for hematopoietic stem cell cycling and development of chronic myeloid leukemia through regulating PRKD2 kinase.PNAS110(6): 2312-7.

7.Zhang H,Li S (2013).DNA Microarray Assay Helps to Identify Functional Genes Specific for Leukemia Stem Cells.Dataset Papers in Science,Article ID 520285.

8.Ho N, Li A, Li S,Zhang H*(2012).Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies.Pharmaceuticals5: 779-801. (*Corresponding author)

9.Zhang H,Li H, Ho N, Li D, Li S (2012). Scd1 plays a tumor suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia.Mol. Cell. Biol.32:1776-1787. (Spotlight Article)

10.Zhang H,Li H, Xi H, Li H (2012).HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells.Blood119(11): 2595-2607.

11.Peng C, Chen Y, Shan Y,Zhang H, Guo Z, Li D, Li S (2012). LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemia stem cells.PLoS One7(6): e38614

12.Sullivan C, Chen Y, Shan Y, Hu Y, Peng C,Zhang H, Kong L, Li S (2011). Functional ramifications for the loss of p-selectin expression on hematopoietic and leukemic stem cells.PLoS One2011 6 (10):e26246

13.Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosamrin AG, Li S (2010). PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemia in mice.Blood115:626-635.

14.Chen Y, Hu Y,Zhang H, Peng C, Li S (2009). Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.Nature Genetics. 41(7): 783-792.

15.Zhang H,Wang ZZ (2008). Mechanisms that mediate stem cell self-renewal and

differentiation.J. Cell Biochem. 103(3): 709-718.

16.Yang YX, Miao ZC,Zhang H, Wang Y, Gao JX, Feng MF (2007). Establishment and characterization of a human telomerase catalytic submit-transduced fetal bone marrow-derived osteoblastic cell line.Differentiation75 (1): 24-34.

17.Zhang H, Miao Z, He Z, Yang Y, Wang Y, Feng M (2005). The existence of epithelial-to-mesenchymal cells with the ability to support hematopoiesis in human fetal liver.Cell Biol. Int.29 (3): 213-219.

18.He ZP, Tan WQ, Tang YF,Zhang H, Feng MF (2004). Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers.Cell Prolif.37 (2):177-187.

19.Zhang H,Miao Z,Wang Y,Feng M (2004).Regulation of haematopoietic stem cells self-renenwal and the role of Wnt signaling in the process.Prog. Biochem. Biophys.31 (7): 579-583.

20.Zhang H, He Z, Feng M (2004). Progress in fetal liver stem cell.CellBiol. of Chin.26 (1): 1-6.

21.He Z,ZhangH, Wang Y, Wang J, Feng M (2003). Progress on plasticity of hepatic stem cells and the mechanisms governing their differentiation.Prog. Biochem. Biophys30 (6): 864-867.

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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