Wei Jiang

Principal Investigator

Medical Research Institute & Zhongnan Hospital, Wuhan University



Email: jiangw.mri@whu.edu.cn; jiangw.pku@gmail.com


Wei Jiang, PhD



Long noncoding RNA (lncRNA); epigenetic regulation; stem cell differentiation; disease modeling; diabetes.

The long-term goal of my career is to apply the basic knowledge from fundamental developmental biology and genetics/epigenetics as well as long noncoding RNAs (lncRNAs), to cell lineage differentiation aiming to uncover the molecule mechanism underlying endodermal disease such as diabetes, liver disease and pancreatic cancer. Stem cell differentiation would be an advanced model together with the CRISPR/Cas9 genome-editing technology.



2015.7 - present: Principal Investigator, Medical Research Institute & Zhongnan Hospital at Wuhan University

2011.2 - 2015.6: Postdoc training with Dr. Yi Zhang at Howard Hughes Medical Institute (HHMI) / Harvard Medical School / Boston Children’s Hospital (UNC-CH before 2012.6)

2005.9 - 2010.7: Ph.D. in Cell Biology, Peking University

2001.9 - 2005.7: B.S. in Biological Science, Peking University (Minor in Computer Software)


Professional Experience

2012-present    Editorial Board Membership, Journal of Molecular Biochemistry

Independent Reviewer/Editor for: Stem Cells, Stem Cell Research, Tissue Engineering, Stem Cells and Development, Stem Cells Translational Medicine, Experimental Cell Research, Journal of Molecular Biochemistry, Stem Cell Reviews and Reports, Cellular Reprogramming, Journal of Stem Cells & Regenerative Medicine, Journal of Diabetes Research, Molecular and Cellular Biochemistry, Stem Cell International.


Honors and Awards

HMS Epigenetics Initiative Travel Grant (2015); Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013); Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015); Excellent Graduate, Peking University (2010).


SELECTED PUBLICATIONS (10/17; total citations >1500 by Google Scholar: http://scholar.google.com/citations?user=ak1phyQAAAAJ&hl=en)

Corresponding-authored #:

1.       Zhang D#, Jiang W#. (2015). From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 65 (5): 468-475. doi: 10.1093/biosci/biv016.

2.       Jiang W#, Liu Y, Liu R, Zhang K, Zhang Y# . (2015). LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 11(1), 137–148.

3.       Jiang W#, Zhang D, Bursac N, Zhang Y#. (2013). WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 (1), 46-52. (Stem Cell Reports is a new journal co-published by Cell Press and ISSCR)


4.       Jiang W, Wang J, Zhang Y#. (2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 23(1), 122-130.

5.       Jiang W*, Sui X*, Zhang D, Liu M, Ding M, Shi Y#, Deng H#. (2011). CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 29(4):609-617.

6.       Zhang D*, Jiang W*, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H#. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 19(4):429-438. (* co-first authors)

Cover story; Featured in the same issue in Cell Research; Sanofi-Aventis Outstanding Research Article Award in Cell Research (2009))

7.       Jiang W*, Bai Z*, Zhang D, Shi Y, Yong J, Chen S, Ding M, Deng H#. (2008). Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 51:1671-1679.

8.       Jiang W*, Shi Y*, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M, Li D#, Deng H#. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 17:333-344.

9.       Jiang W, Chen L#, Hu X, Nie L. (2008). Study on ultraviolet spectrophotometry for determination the content of IgG in animal serum product. Chinese Journal of Biochemical Pharmaceutics 29(2):119-120.

10.    Chung YG*, Matoba S*, Liu Y, Eum JH, Lu F, Jiang W, Lee JE, Sepilian V, Cha KY, Lee DR#, Zhang Y#. (2015). Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells. Cell Stem Cell 2015 Oct 28. doi: 10.1016/j.stem.2015.10.001.


Patents FILED

1.       PCT/CN2006/000683 (WO/2006/108361). Deng H, Ding M, Shi Y, Jiang W, Hou L, Tang F.

2.       CN201110151722.3 (in China). Deng H, Jiang W, Sui X, Zhang D, Liu M, Yin M.


Oral talks

1.       LncRNA and Endoderm Differentiation.  The 5th RNAi China, 2015 Sep 12th, Kunshan, China.

2.       LncRNA DEANR1 Regulates Human Endoderm Differentiation by Facilitating FOXA2 Activation. ISSCR 11th Annual Meeting, 2015 Jun 25th, Stockholm, Sweden.

3.       Histone H3K27me3 Demethylases KDM6A and KDM6B Modulate Definitive Endoderm Differentiation from Human ESCs by Regulating WNT Signaling Pathway. Beta Cell Biology Consortium (BCBC) Investigator Retreat, 2012 May 3rd, Chantilly, VA, USA.

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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