Ying-Ying Pu

Ying-Ying Pu, PhD

Professor, Principle Investigator

Medical Research Institute, Wuhan University


Email: yingyingpu@whu.edu.cn


2001-2005  B.A.,

 Plant Biotechnology, Shanghai Jiaotong University, China

2005-2011  PhD,

 School of Life Science, Peking University

2007-2009  Joint PhD,

Japan National Agricultural Research Center

Professional Experience:

2011-2015 Postdoctoral Researcher, 

BIOPIC, Peking University (Xiaoliang Sunney Xie & Fan Bai Lab)

2012 Visiting Scholar

Chemistry and Chemical Biology, Harvard University (Xiaoliang Sunney Xie Lab)

2015 - 2018 Assistant Research Fellow, 

BIOPIC, Peking University

2019-now   Professor,

Medical Research Institute, Wuhan University, China

Research Areas:

Bacterial drug tolerance, infection and immunity, biodynamic imaging, single-cell sequencing

Selected Publications:

       1) Pu Y, Li Y, Bai F, et al. (2018). ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance. Molecular Cell, Nov. 21, 2018, online. 

       2) Pu Y, Ke Y, Bai F. (2017). Active efflux in dormant bacterial cells - New insights into antibiotic persistence. Drug Resist Updat 30, 7-14.

3) Jin L, Qin Q, Wang Y, Pu Y, Li Y, et al. (2017). Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development. PLoS Pathogens 12(9):e1005847.

4) Pu Y, Zhao Z, Li Y, Bai F, Xie X, et al. (2016). Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells. Molecular Cell, 62, 284-294. (Highlighted by Nature https://www.nature.com/articles/nature18442 and Nature Review Microbiology https://www.nature.com/articles/nrmicro.2016.72)

5) Guo X, Jin X, Lv X, Pu Y, Bai F*. (2015) Real Time Visualization of Perylene Nano-clusters (PNCs) in Water and Their Partitioning to Graphene Surface and Macrophage Cells. Environmental Science & Technology, 49 (13): 7926-7933.

6) Liu Y, Yang J, Zhao Z, Pu Y*, Bai F*. (2014) Bacterial Persistence. Science China Chemistry, 57 (12): 1625-1633 (CORRESPONDANT AUTHOR)

7) Pu Y, Kikuchi A, Moriyasu Y, Tomara M, Jin Y, Suga H, Wei T, Li Y, Omura T. (2011) Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects -implications for the virus origin. Journal of Virology, 85 (6): 2975-2979.

8) Akita F, Higashiura A, Shimizi T, Pu Y, Suzuki M, Ichiki T, Sasaya T, Kanamaru S, Arisaka F, Tsukihara T, Nakagawa A, Omura T. (2012) Crystal Structure and Octamerization of the Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus. Journal of Virology, 86 (2): 746-756.

9) Zhou F, Pu Y, Wei T, Liu H, Deng W, Wei CH, Ding B, Omura T, Li Y. (2007). The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells. Proceedings of the National Academy of Sciences USA. 104(49): 19547-19552.

10) Zhou F, Wu G, Deng W, Pu Y, Wei C, Li Y. (2007). Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8. Febs Letters 581(1): 34-40. 

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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