Ying Zhang


 Address:Bldg.8 Rm 1424

                 Medical Research Institute

                 Wuhan University

                 Wuhan, Hubei Province, P.R.China 430071

  Email:     Ying.Zhang84@whu.edu.cn

  Phone:   027-68750336


Target gene insertion in Hematopoietic Stem Cell; CRISPR/Cas9 mediated gene correction for treating lysosomal storage disorders;


2018-            Professor, Medical Research Institute, Wuhan University, China

2015-2018,  Senior Scientist, Group Lead of HDR in HSC, CRISPR Therapeutics Inc.  

2012-2015,  Postdoctoral fellow, Dept. of Genetics, Harvard Medical School

2006-2012,  Ph.D. in Cell, Stem Cell, and Developmental Biology, University of Colorado Anschutz Medical Campus

2002-2006,  B.S. in Biology, Nankai University, Tianjin, China


1. Zhang HX, Zhang Y*, Yin H*. Molecular Therapy In press 2019.

2. Liu Y, Lin H, Liu Z, Ouyang H, Signer R, Huang S, Chen S, Wu F, Zhang Y, Lin D, Zhu J, Patel S, Qiu A, Li G, Cai H, Cao G, Zhu J, Chen D, Shang F, Liu X, Luo L, Granet D, Li X, Morrison S, Zhang K. Lens regeneration using endogenous stem cells with gain of visual function. Nature. 2016 Mar 17;531(7594):323-8.

3. Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, Sellarole M, Vries W, Lu W, Lang R, John S, Maas R. Crim1 regulates integrin signaling in murine lens development. Development. 2016 Jan 15;143(2):356-66.

4. Chen J, Zhang Y, Wilde J, Hansen K, Lai F, Niswander L. Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nature Communications. 2014 May 30;5:3885.

5. Zhang Y, Niswander L. Zic2 is required for enteric nervous system development and neurite  outgrowth: a mouse model of enteric hyperplasia and dysplasia. Neurogastroenterol Motil. 2013 Jun;25(6):538-41.

6. Zhang, Y. and Niswander, L.  Phactr4: a new integrin modulator required for directional migration of  enteric neural crest cells. Cell Adh Migr. 2012  Sep-Oct;6(5):419-23.

7. Zhang Y, Kim TH, Niswander L. Phactr4 regulates directional migration of Enteric Neural Crest through PP1, integrin signaling and cofilin activity. Genes & Development. 2012 Jan 1;26(1):69-81.
(Evaluated in Faculty of 1000 and highlighted at Genes Dev. 2012 Jan 1; 26(1):1-5. Nature Cell Biology 14, 130 (2012)  doi:10.1038 Sci. Signal., 10 January 2012, Vol. 5, Issue 206, p. ec12)

8. Marean A, Graf A, Zhang Y, Niswander L. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet. 2011 Sep 15;20(18):3678-83.
Book Chapter "Genome Editing for Genetic Lung Diseases" Pharmaceutical Inhalation Aerosol Technology Third Edition.

Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

Copyright @ 2016 Medical Research Institute