Yixian Cui, PhD

Professor, Principle Investigator

Department of Metabolic Biology and Diseases, Medical Research Institute;

Frontier Science Center for Immunology and Metabolism; Wuhan University, Wuhan, China

Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, China

Email yixian.cui@whu.edu.cn

Phone: 027-87267099


2003-2007 B.S. in Biology

College of Biology, Hunan University, China

2007-2013 Ph. D. in Biology, Supervisor: Dr. Bing Zhou

School of Life Sciences, Tsinghua University, China


Working Experiences

2013-2015  Postdoctoral Researcher, Supervisor: Dr. Bing Zhou

School of Life Sciences, Tsinghua University, China

2015-2019  Postdoctoral Researcher and Assistant project scientist,

Supervisor: Dr. Susan Ferro-Novick, School of Medicine, University of California San Diego, USA

2020-present  Professor; Principle Investigator

Medical Research Institute, Wuhan University, China


Research Areas

Our lab is studying the molecular mechanism of selective autophagy (mainly focused on ER-phagy) and its disease relevance (mainly focused on neurodegeneration). We use yeast, fruit fly and mouse as research model organisms.


Selected Publications

[1] Yixian Cui, Smriti Parashar, Muhammad Zahoor, Patrick G. Needham, Muriel Mari, Ming Zhu, Shuliang Chen, Hsuan-Chung Ho, Fulvio Reggiori, Hesso Farhan, Jeffrey L. Brodsky, and Susan Ferro-Novick*. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science, 365, 53 –60, 2019 (Article, IF2019 =41, first author);

[2] Yixian Cui, Smriti Parashar, and Susan Ferro-Novick*. A new role for a COPII cargo adaptor in autophagy. Autophagy, Dec 3:1-3, 2019 (Commentary, IF2019 =11, first author);

[3] Shuliang Chen, Yixian Cui, Smriti Parashar, Peter J. Novick*, and Susan Ferro-Novick*. ER-phagy requires Lnp1, a protein that stabilizes rearrangements of the ER network. Proc Natl Acad Sci U S A. 115(27), E6237-E6244, 2018 (Article, IF2019=9.6, co-author);

[4] Shuliang Chen, Muriel Mari, Smriti Parashar, Dongmei Liu, Yixian Cui, Fulvio Reggiori, Peter J. Novick*, Susan Ferro-Novick*. Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A 117(31), 18530-18539, 2020 (Article, IF2020=9.4, co-author);

[5] Yixian Cui* Shanke Zhao, Xudong Wang, Bing Zhou*. A novel Drosophila mitochondrial carrier protein acts as a Mg2+ exporter in fine-tuning mitochondrial Mg2+ homeostasis. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1863, 30–39, 2016 (Article, IF2019=4.7, co-first author and co-corresponding author);

[6] Yixian Cui*, Shanke Zhao, Juan Wang, Xudong Wang, Bingquan Gao, Qiangwang Fan, Fei Sun, Bing Zhou*. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter. Biochimica et Biophysica Acta (BBA) –Molecular Cell Research 1853, 724–732, 2015 (Article, IF2019=4.7, co-first author and co-corresponding author);

[7] Yixian Cui, Shanke Zhao, Zhihao Wu, Pinghua Dai, Bing Zhou*. Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast. Molecular Biology of the Cell 23, 22, 4373-4382, 2012 (Article, IF2019=3.9, first author).


Tel: 0086-27-68750205 Fax: 0086-27-68759675  Email: mri@whu.edu.cn

Contact address: Donghu Road, No. 115, Wuchang District, Wuhan, Hubei Province, P.R. China. 430071

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