Lab Address: Bldg. #8, Room #1126
Medical Research Institute
Wuhan University
Wuhan, Hubei Province, P.R.China. 430071
Emal: youngnam_jin@whu.edu.cn
Phone: +86 13628627281
Education
1997 |
B.S. |
Inha University |
Korea |
1999 |
M.S. |
Seoul National University |
Korea |
2010 |
Ph.D. |
University of Rochester, |
USA |
Work Experience
2011-2017 |
Research fellow |
Massachusetts General Hospital/Harvard Medical School |
2018 |
Assistant professor (Research) |
University of Utah |
2018-present |
Professor |
Medical Research Institute,Wuhan University |
Awards
2015-2017 |
T32 Grant “Cell and Molecular Training for Cardiovascular Biology” 5 T32 HL 7208-38 |
04/02/2014 |
MGH Scientific Advisory Committee 2014 Poster of Distinction Award |
02/02/2014 |
Keystone Symposia Future of Science Fund scholarship: RNA silencing |
2009 |
Medical Faculty Council (MFC) Travel Award for Basic Sciences |
Research Area
chemical screening in embryogenesis, neural diseases, and cancer models using zebrafish or cell lines, study of mechanisms of drug’s action, RNA biology (e.g. translation)
Selected Publications
1. Jin YN*#, Schlueter PJ*, Jurisch-Yaksi N, Lam PY, Jin S, Hwang, WY, Yeh JR, Yoshigo M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT#. (2018) Non-canonical translation via deadenylated 3’UTRs maintains primordial germ cells. Nat Chem Biol.
2. Metelo AM, Noonan HR, Li X, Jin Y, Baker R, Kamentsky L, Zhang Y, van Rooijen E, Shin J, Carpenter AE, Yeh JR, Peterson RT, Iliopoulos O. (2015) Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model.J Clin Invest. 125(5):1987-97.
3. Nath AK, Ryu JH, Jin YN, Roberts LD, Dejam A, Gerszten RE, Peterson RT. (2015) PTPMT1 inhibition lowers glucose through succinate dehydrogenase phosphorylation. Cell Rep. 10(5): 694-701.
4. Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GVW. (2014) Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nat Commun. 5:3496.
5. Quintanilla RA, Jin YN, von Bernhardi R, Johnson GV. (2013) Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease. Mol Neurodegener. 8:45.
6. Jin YN, Yanxun VY, Gundemir S, Jo C, Cui M, Tieu K, Johnson GVW. (2013) Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin. PLoS One 8(3):e57932.
7. Kokel D, Cheung CYJ, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 9(4):257-63.
8. Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, MacRae CA, Peterson RT..(2013) An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen.18(1):108-15.
9. Jin YN, Chen PC, Watson JA, Walters BJ, Phillips SE, Green K, Schmidt R, Wilson JA, Johnson GV, Roberson ED, Dobrunz LE, Wilson SM. (2012) Usp14 deficiency increases Tau phosphorylation without altering tau degradation or causing tau-dependent deficits. PLoS One 7(10):e47884.
10. Jin YN, Hwang WY, Jo C, Johnson GV. (2012) Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ. PLoS One 7(1):e30406.
11. Quintanilla RA, Dolan PJ, Jin YN, Johnson GV. (2012) Truncated tau and Aβ cooperatively impair mitochondria in primary neurons. Neurobiol Aging.33(3):619.e25-35.
12. Jin YNand Johnson GVW. (2010) The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease. J Bioenerg Biomembr.42(3):199-205.
