Selected Publications:

1: Ren P, Niu D, Chang S, Yu L, Ren J, Ma Y, Lan K*. RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription. J Virol. 2024 Feb 20;98(2):e0156723.

2: Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y, Guo M, Wang X, Huang Z, Inuzuka H, Chen L, Chu C, Liu J, Zhang T, Rezaeian AH, Liu J, Kaniskan HÜ, Zhong B, Zhang J, Letko M, Jin J*, Lan K*, Wei W*. USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Sci Transl Med. 2023 Dec 6;15(725):eadh7668.

3: Fan H, Zhou L, Lv J, Yang S, Chen G, Liu X, Han C, Tan X, Qian S, Wu Z, Yu S, Guo M, Zhu C*, Chen Y*, Lan K*. Bacterial coinfections contribute to severe COVID-19 in winter. Cell Res. 2023 Jul;33(7):562-564.

4: Zhao Y, Ni W, Liang S, Dong L, Xiang M, Cai Z, Niu D, Zhang Q, Wang D, Zheng Y, Zhang Z, Zhou D, Guo W, Pan Y, Wu X, Yang Y, Jing Z, Jiang Y, Chen Y, Yan H, Zhou Y, Xu K*, Lan K*. Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice. Sci Transl Med. 2023 Jan 4;15(677):eabo3332.

5: Ma C, Chen X, Mei F, Xiong Q, Liu Q, Dong L, Liu C, Zou W, Zhan F, Hu B, Liu Y, Liu F, Zhou L, Xu J, Jiang Y, Xu K, Cai K*, Chen Y*, Yan H*, Lan K*. Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 2022 Dec;11(1):567-572.

6: Han C, Zhang D, Gui C, Huang L, Chang S, Dong L, Bai L, Wu S, Lan K*. KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system. PLoS Pathog. 2022 Aug 1;18(8):e1010744

7: Liu Q, Xiong Q, Mei F, Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K*, Yan H*, Chen Y*, Lan K*. Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China. Innovation. 2022 Jan 25;3(1):100181.

8: Dong L, Dong J, Xiang M, Lei P, Li Z, Zhang F, Sun X, Niu D, Bai L*, Lan K*. NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase. PLoS Pathog. 2021 Jun 2;17(6):e1009645.

9: Wang D, Jiang A, Feng J, Li G, Guo D, Sajid M, Wu K, Zhang Q, Ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K*, Chen Y*, Zhou Y*. The SARS-CoV-2 subgenome landscape and its novel regulatory features. Mol Cell. 2021 May 20;81(10):2135-2147

10: Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K*, Chen Y*, Zhao H*. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nat Ecol Evol. 2021 May;5(5):600-608.

11: Bai L, Zhao Y, Dong J, Liang S, Guo M, Liu X, Wang X, Huang Z, Sun X, Zhang Z, Dong L, Liu Q, Zheng Y, Niu D, Xiang M, Song K, Ye J, Zheng W, Tang Z, Tang M, Zhou Y, Shen C, Dai M, Zhou L, Chen Y, Yan H, Lan K*, Xu K*. Coinfection with influenza A virus enhances SARS-CoV-2 infectivity. Cell Res. 2021 Apr;31(4):395-403.

12: Wei X, Dong J, Cheng CC, Ji M, Yu L, Luo S, Wu S, Bai L, Lan K*. Host RAB11FIP5 protein inhibits the release of Kaposi's sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45. PLoS Pathog. 2020 Dec 14;16(12):e1009099.

13: Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Liu Y, Zhou Y, Lan K*, Chen Y*. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg Microbes Infect. 2020 Dec;9(1):761-770.

14: Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, Liu X, Xu K, Ho KF, Kan H*, Fu Q*, Lan K*. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. 2020 Jun;582(7813):557-560.

15: Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, Chen L, Liang L, Zhou J, You L, Wu P, Zhang B, Lu Y, Xia L, Huang L, Yang Y, Liu F, Semple MG, Cowling BJ, Lan K*, Sun Z*, Yu H*, Liu Y*. Detection of Covid-19 in Children in Early January 2020 in Wuhan, China. N Engl J Med. 2020 Apr 2;382(14):1370-1371.

16: Chen L, Liu W, Zhang Q, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y, Li Y*, Shi M*, Lan K*, Liu Y*. RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect. 2020 Feb 5;9(1):313-319.

17: Wei X, Bai L, Dong L, Liu H, Xing P, Zhou Z, Wu S, Lan K*. NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA. PLoS Pathog. 2019 Nov 21;15(11):e1008160.

18: Bai L, Dong J, Liu Z, Rao Y, Feng P, Lan K*. Viperin catalyzes methionine oxidation to promote protein expression and function of helicases. Sci Adv. 2019 Aug 28;5(8):eaax1031.

19: Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K*. NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 Feb 27;15(2):e1007628.

20: Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM*, Dong YH*, Lan K*. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function. PLoS Pathog. 2018 Aug 10;14(8):e1007232.

21: Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog. 2017 Sep 28;13(9):e1006580.

22: Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues. PLoS Pathog. 2017 Jan 24;13(1):e1006167.

23: Li S, Hu H, He Z, Liang D, Sun R, Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct 19;12(10):e1005900.

24: Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao SJ, Lan K*. Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. PLoS Pathog. 2014 Jul 10;10(7):e1004253.

25: Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K*. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε. Cell Res. 2011 May;21(5):793-806.