Education

1997-2001 B.S., Shandong Normal University, China

2001-2004 M.S., Institute of Zoology, Chinese Academy of Sciences, China

2008-2012 Ph.D., University of Massachusetts Medical School, USA

Academic Experience

2004-2006 Research Associate, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

2006-2008 Research Associate, The Jackson Laboratory, USA

2012-2016 Postdoctoral Fellow, Dana Farber Cancer Institute, Harvard Medical School, USA

2016- Professor, Medical Research Institute, Wuhan University, China

2016- Professor, School & Hospital of Stomatology, Wuhan University, China

2019- Professor, Frontier Science Center for Immunology and Metabolism, Wuhan University, China

2022- Professor, Taikang Center for Life and Medical Sciences, Wuhan University, China

Awards & Honors

The 10th“Zhu Yubi” Medical Award, Wuhan University (2023)

China’s Top 10 Achievements in Hematology in 2021 (2022)

China’s Top 10 Achievements in Hematology in 2020 (2021)

Social Service

Member, Chinese Association for Blood Sciences, Chinese Association for Physiological Sciences (2018-)

Member, Chinese Association for Pathophysiology (2019-)

Member, Chinese Stomatological Association (2019-)

Member, Chinese Society for Cell Biology (2019-)

Associate Editor, Cellular Oncology (2022-)

Editorial Board Member, Blood Science (2024-)

Representative Publications

1. Ying Cheng^#, Zhuying Gao^#, Tiantian Zhang^#…Haojian Zhang*. Decoding m⁶A RNA methylome identifies PRMT6-regulated lipid transport promotes AML stem cell maintenance. Cell Stem Cell, 2023, 30:69-85.

2. Rong Yin^#, Jiwei Chang^#, Yashu Li^#…Haojian Zhang*. Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell, 2022, 29: 149-159.

3. Jiazhen Wang^#, Yicun Li^#, Peipei Wang^#, Guoqiang Han^#…Haojian Zhang*. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell, 2020, 27:81-97.

4. Mengdie Feng^#, Xueqin Xie^#, Guoqiang Han^#…Haojian Zhang*. YBX1 is required for maintaining myeloid leukemia cell survival by regu lating BCL2 stability in an m6A-dependent manner. Blood, 2021, 138(1): 71-85.

5. Qifan Wang^#, Jin Hu^#, Guoqiang Han^#…Haojian Zhang*. PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation. Cell Reports, 2022, 38:110603.

6. Peipei Wang#, Jing Wang#... Haojian Zhang*. Deubiquitinase USP9X stabilizes RNA m6A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival. Journal of Biological Chemistry, 2023, 299: 105055.

7. Tong Zhang#, Manman Cui#... Haojian Zhang*. Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity. Haematologica, 2023, 108: 2410-2421.

8. Jianfei Liang#, Jing Wang#…Haojian Zhang*. PTIP safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis. Science Bulletin, 2024, 69:2099-2113.

9. Haojian Zhang#, David Kozono, Kevin O’Connor…Alan D’Andrea*. TGF-β Inhibition rescues hematopoietic stem cell defects and bone marrow failure in fanconi anemia. Cell Stem Cell, 2016, 18, 668-681.

10. Haojian Zhang#, Cong Peng, Sheng Zhi…Shaoguang Li*. Tumor suppressor role of the Blk pathway in cancer stem cells of chronic myeloid leukemia. Nature Genetics, 2012 44: 861-871.