FACULTY

Zhi-Yuan Hu

Final Degree:PhD

Professional Title:Professor

Major:Functional genomics, bioinformatics

Research Direction:Single-cell multi-omics, gene regulatory network, development and disease

Email:zhiyuan.hu[at]whu.edu.cn

Tel:

Detailed Introduction

Education

2011-2015 B.S. in Biological Science, Peking University, China

2015-2020 DPhil in Clinical Medicine, University of Oxford, United Kingdom

Academic Experience

2020-2020 Postdoctoral Research Assistant, Nuffield Department of Women’s & Reproductive Health, University of Oxford, United Kingdom

2021-2023 Postdoctoral Scientist, Radcliffe Department of Medicine, University of Oxford, United Kingdom

2023- Professor and Principal Investigator, Medical Research Institute, Wuhan University, China

Awards & Honors

Junior Research Fellowship, Wolfson College, University of Oxford (2022)

Award for the most impactful paper in 2020, Columbia Hospital For Women Research Foundation (2021)

NIHR Oxford Biomedical Research Centre Small Grants in Health Sciences (2020)

WHG Public Engagement Seed Award, University of Oxford (2019)

AACR-Margaret Foti Scholar-in-Training Award, AACR (2019)

Representative Publications

1. Z. Hu, A. Ahmed*, C. Yau*. CIDER: an interpretable meta-clustering framework for single-cell RNA- seq data integration and evaluation. Genome Biology 22, 337 (2021).

2. Z. Hu†, P. Cunnea†, Z. Zhong, H. Lu, O. Osagie, L. Campo, M. Artibani, K. Nixon, J. Ploski, L. Santana Gonzalez, A. Alsaadi, N. Wietek, S. Damato, S. Dhar, S. P. Blagden, C. Yau, J. Hester, A. Albukhari, E. O. Aboagye, C. Fotopoulou*, A. A. Ahmed*. The Oxford Classic links epithelial-mesenchymal transition to immunosuppression in poor prognosis ovarian cancers. Clinical Cancer Research (2021).

3. Y. Liu, Z. Hu, J. Cheng, P. Siejka-Zielinska, J. Chen, M. Inoue, A. A. Ahmed, C.-X. Song. Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution. Nature Communications 12, 618 (2021).

4.Z. Hu, M. Artibani, A. Alsaadi, N. Wietek, M. Morotti, T. Shi, Z. Zhong, L. Santana Gonzalez, S. El- Sahhar, M. KaramiNejadRanjbar, G. Mallett, Y. Feng, K. Masuda, Y. Zheng, K. Chong, S. Damato, S. Dhar, L. Campo, R. Garruto Campanile, V. Rai, D. Maldonado-Perez, S. Jones, V. Cerundolo, T. Sauka-Spengler, C. Yau*, A. A. Ahmed*. The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells. Cancer Cell 37(2), 226–242.e7 (2020).

5. Z. Hu, C. Yau* and A. Ahmed*. A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay. Nature Communications 8, 15943 (2017).


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