Research

The molecular mechanisms of antiviral natural immune signaling, inflammatory cytokine-mediated inflammatory response and tumorigenesis.

Representative Publications

1. Xu S, Deng K, Lu C, Fu X, Zhu Q, Wan S, Zhang L, Huang Y, Nie L, Cai H, Wang Q, Chen Y, Yan H, Xu K, Zhou L, Lu M, Zhu Y, Liu S*, Lu Z*. Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects. Metabolism-Clinical and Experimental 2024 (10.1016/j.metabol.2024.155832)

2. He Q, Huang Y, Nie L,Ren S. Xu G, Deng F, Cheng Z. Zuo Q,Zhang L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhu Y*,Liu S*. MAVS integrates glucose metabolism and RIG-I-like receptor signaling. Nature Communications 2023; 14, 5343.

3. Cai H, Xiong W, Zhu H, Wang Q, Liu S*, Lu Z*. Protein O-GlcNAcylation in Multiple Immune Cells and Its Therapeutic Potential (Review). Frontiers in Immunology 2023; 1209970

4. Zhou L, He R, Fang P, Li M, Yu H, Zhu Y，Liu S*. Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition. Nature Communications 2021;12,98.

5. Wang Q, Fang P, He R, Li M, Yu H, Zhou L, Yu Y, Wang F, Liu S*. O-GlcNAc Transferase Promotes Influenza A Virus-Induced Cytokine Storm by Targeting Interferon Regulatory Factor-5. Science Advances 2020;6:16, eaaz7086.

6. Yu H, Li M, He R, Fang P, Wang Q, Yu Y, Wang F, Zhou L, Zhang Y, Chen A, Peng N, Liu S*. Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity. Hepatology 2020;72: 518-534.