Education
2004-2008 B.S. in College of Life Sciences, Wuhan University, Wuhan, China
2008-2013 Ph.D. in College of Life Sciences, Wuhan University, Wuhan, China
Academic Experience
2013-2022 Lecturer, and associate professor, College of Life Sciences, Wuhan University, Wuhan, China
2016-2017 Postdoctoral fellow, MD Anderson Cancer Center, USA
2022- Professor, College of Life Sciences, Wuhan University, Wuhan, China
2023- Professor, Medical Research Institute, Wuhan University, China
Representative Publications
(1) Xu Yanran#, Shi Mengling#, Zhang Yu#, Kong Na, Wang Cong, Xiao Yifeng, Du Shishen, Zhu Qiyun, Lei Caoqi*. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. PNAS, 2022.
(2) Zeng Yan, Xu Shuai, Wei Yanli, Zhang Xuefeng, Wang Qian, Jia Yane, Wang Wanbing, Han Lu, Chen Zhaoshan, Wang Zhengxiang, Zhang Bo, Chen Hualan, Lei Caoqi*, Zhu Qiyun*. The PB1 Protein of Influenza A Virus Inhibits the Innate Immune Response by Targeting MAVS for NBR1-Mediated Selective Autophagic Degradation. Plos Pathogens, 2021. doi.org/10.1371/journal.ppat.1009300
(3) Xu Yanran#, Lei Caoqi*. TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses. Frontiers in Immunology, 2021. doi.org/10.3389/fimmu.2020.608976
(4) Wei Yanli#, Zeng Yan#, Zhang Xuegang, Xu Shuai, Wang Zhengxiang, Du Yingying, Zhang Bo, Lei Caoqi*, Zhu Qiyun*. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. Journal of Virology, 2020, 23;94(24):e01640-20
(5) Zhong Xuan#, Feng Lu, Xu Wenhua, Wuxin, Ding Yidi, Zhou Yan, Lei Caoqi*, Shu Hongbing*. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating its ligand binding. Cellular & Molecular Immunology, 2020, 17(7):741-752.
(6) Lei Caoqi#*, Wu Xin#, Zhong Xuan, Jiang Lu, Zhong Bo, Shu Hongbing*. USP19 inhibits TNFa- and IL-1b-triggered NF-kB activation by deubiquitinating TAK1. Journal of Immunology, 2019, 203(1):259-268.
(7) Chen Zhen#, Lei Caoqi#, Wang Chao, Li Nan, Mrinal Srivastava, Tang Mengfan, Zhang Huimin, Choi Jongmin, Jung Sungyun, Qin Jun, Chen Junjie*. Global Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics. Nature Communications, 2019, 10: 104
(8) Wang Junyong#, Zeng Yan, Xu Shuai, Yang Jiayun, Wang Wanbing, Ge Jinying, Yin Lei, Wang Zhengxiang, Han Lu, Cui Xiaole, Zhong Bo, Shu Hongbing, Chen Hualan, Lei Caoqi*, Zhu Qiyun*, A naturally occurring deletion in the effector domain of H5N1 influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity. Journal of Virology, 2018, 92(11): e00149-18
(9) Wang Junyong#, Lei Caoqi*, Ji Yanhong, Zhou Hongbo, Ren Yujie, Peng Qianqian, Zeng Yan, Jia Yane, Ge Jinying, Zhong Bo, Li Yu, Wei Jianzhong, Shu Hongbing, Zhu Qiyun*, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA. Journal of Immunology, 2016, 197(12):4704-4713.
(10) Lei Caoqi#, Zhang Yu, Li Mi, Jiang Liqun, Zhong Bo, Kim Yonghao, Shu Hongbing*, ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. Journal of Innate Immunity, 2015, 7(2):153-164.
(11) Lei Caoqi#, Zhang Yu, Xia Tian, Jiang Liqun, Zhong Bo, Shu Hongbing*, FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. Journal of Biological Chemistry, 2013, 288(18):12596-12604.
(12) Lei Caoqi#, Zhong Bo, Zhang Yu, Zhang Jing, Wang Shuai, Shu Hongbing*， Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity, 2010, 33(6):878-889.
