Education
2001.9-2005.6 B.A. in English, Foreign Languages Department, China University of Geosciences, Wuhan, China
2003.2-2005.6 B.S. in Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China
2005.9-2010.6 Ph.D. in Cell Biology, College of Life Sciences, Wuhan University, Wuhan, China
Academic Experience
2010.07-2013.05 Postdoctoral Fellow, Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, TX
2013.03-present Professor, College of Life Sciences, Wuhan University, Wuhan, China
2016.09-present Professor, College of Life Sciences/Medical Research Institute, Wuhan University, Wuhan, China
20118.12-present Professor (Tenured with outstanding score), College of Life Sciences/ Medical Research Institute, Wuhan University, Wuhan, China
Awards & Honors
2020 Gu Xiaocheng Lecture Award, The Gu Xiaocheng Memorial Fund, USA
2020 AAI Laboratory Travel Grant, American Association of Immunologists, USA
2017 CST-Young Investigator Award, Chinese Society of Cell Biology, China
2016 Zhu Yu-Bi Medical Research Award, Wuhan University
2015 National Natural Science Award, China
2015 One of Ten Excellent Young Faculties of Wuhan University, China
2012 National Excellent Doctoral Dissertation, Ministry of Education, China
2012 Abstract Award, American Association of Immunologists, USA
2011 Odyssey Fellowship, MD Anderson Cancer Center
2010 Invited to the 60th Lindau Nobel Laureates Meeting, Germany
2009 The Ray Wu Prize Fellow, The Ray Wu Memorial Fund, USA (http://www.raywumemorialfund.org/2009winner.php)
Social Service
Editorial Member, Journal of Cell Biology
Associate Editor, Cell Insight
Editor, Virologica Sinica
Editor, Infectious Diseases and Immunity
Chinese Society for Cell Biology
Chinese Society for Immune Cell Biology
Chinese Society for Immunology
American Association of Immunologists
Representative Publications
1. Guo, YY#, Gap Y#, Zhao YL#, Xie C#, Gan H, Chen X, Yang LP, Hu J, Shu HB, Zhong B*, Lin D*, Yao J*. Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. Cell Rep. 2024, 43(4):114095.
2. Zhang ZD, Shi CR, Li FX, Gan H, Wei Y, Zhang Q, Shuai X, Chen M, Lin YL, Xiong TC, Chen X*, Zhong B*, Lin D*. Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115. Cell Mol Immunol. 2024, 21(3):275-291. doi: 10.1038/s41423-024-01131-3.
3. Yu K, Guo YY, Liuyu T, Wang P, Zhang ZD, Lin D*, Zhong B*. The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection. Cell Insight, 2023, 2(3): 100100. doi: 10.1016/j.cellin.2023.100100.
4. Xiong TC#, Wei MC#, Li FX#, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B*, Zhang ZD*, Lin D*. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun, 2022, 13: 5973. doi: /10.1038/s41467-022-33671-5.
5. An R, Wang P, Guo H, Liuyu T, Zhong B*, Zhang ZD*. USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network. Cell Insight, 2022, 1(4): 100047. doi: 10.1016/j.cellin.2022.100047.
6. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B*, Lin D*. RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13. Adv Sci, 2022, 9(16): 2105391. doi: 10.1002/advs.202105391.
7. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling. Adv Sci, 2022, 9: 2103035. doi: 10.1002/advs.202103035.
8. Zhang ZD, Zhong B*. Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight, 2022, 1(1): 100001. doi: 10.1016/j.cellin.2021.100001.
9. Wang P#, Yang W#, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death. Adv Sci, 2021, 8(19): 2101501. doi: 10.1002/advs.202101501.
10. Wu X, Wang Y, Huang R, Gai Q, Liu H, Shi M, Zhang X, Zuo Y, Chen L, Zhao Q, Shi Y, Wang F, Yan X, Lu H, Xu S, Yao X, Chen L, Zhang X, Tian Y, Yang Z, Zhong B, Dong C, Wang Y*, Bian XW*, Liu X*. SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation. Science, 2020, 369(6506):984-988. doi: 10.1126/science.aba6652.
11. Zhang M#, Yang W#, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D*, Chu Q*, Zhong B*. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun, 2020, 11: 6119. Nov 30, doi: 10.1038/s41467-020-19973-6.
12. Zhang ZD#, Xiong TC#, Yao SQ, Wei MC, Chen M, Lin D, Zhong B*. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun, 2020, 11: 5536. Nov 2, doi: 10.1038/s41467-020-19318-3.
13. Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C, Zhong B*. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nat Cancer, 2020, 1: 811-825. July 6, doi: 10.1038/s43018-020-0089-4.
14. Zhang Q, Tang Z, An R, Ye L, Zhong B*. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res, 2020, 30, 914-927. May 26, doi: 10.1038/s41422-020-0341-6.
15. Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B*. USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J Exp. Med., 2020, 217, 5: e20191174.
16. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat Commun, 2019, 10(1): 3233.
17. Liu X*, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, Huang R, Wu J, Zhao Q, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X, Nurieva R, Ye L, Tian Q, Bian XW*, Dong C*. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature, 2019, 567(7749): 525-529.
18. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Plos Pathog, 2019, 15(4): e1007680.
19. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA. J Immunol, 2019, 202(8):2397-2406.
20. Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D, Zhong B*, Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS. Cell Res, 2019, 29(1):67-79.
21. Zhao Y, Wang XM, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B*, USP2a supports metastasis by tuning TGF-b signaling. Cell Rep, 2018, 22(9):2442-2454.
22. Li K, Zhong B*, Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules. Immune Network. 2018, 18(1):e4. (Invited review)
23. Lu B#, Ren Y#, Sun X#, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B*, Huang Z*. Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3. Cell Host Microbe, 2017, 22(1):86-98.e4. (Cover story)
24. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B*. USP13 negatively regulates antiviral responses by deubiquitinating STING. Nat Commun. 2017, May 23; 8:15534. 10.1038/NCOMMS15534.
25. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu QY, Yao J, Shu HB, Zhong B*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016, 26(12): 1302-1319.
26. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B*. The type I interferon-IRF7 axis mediates transcriptional expression of Usp25 gene. J Biol Chem. 2016, 291(25): 13206-13215.
27. Lin D, Zhang M, Zhang MX, Ren YJ, Jin J, Zhao Q, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329.
28. Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155. (Invited Review)
29. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C*. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014, 507(7493):513-8.
30. Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C*. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013). Sci Signal. 6, ra35.
31. Liu XK#, Li HX#, Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X* and Dong C*. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013). J Exp Med. 210, 1575-90. (#Co-first authors)
32. Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C*. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012). Nat Immunol. 13, 1110-17.
33. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB*. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010). J Immunol. 184, 6249-6255.
34. Zhong B, Wang YY and Shu HB*. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010). Frontier in Biology 5, 12-31.
35. Zhong B, Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB*. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009). Immunity 30, 397-407.
36. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB*. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008). Immunity 29, 538–550.
37. Zhong B, Tien P and Shu HB*. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006). Virology 352, 14-21.