Research

Extracellular Vesicles in Tumor Biology and Therapy

Representative Publications

1. Liu JY^#, Yu ZL^#, Fu QY, Zhang LZ, Li JB, Wu M, Liu B, Chen G*（2023）. Immunosuppressive effect of small extracellular vesicle PD-L1 is restricted by co-expression of CD80. Brit J Cancer 129:925-934.

2. Zhang LZ^#, Yang JG^#, Xia HF, Huang J, Liu HM, Wu M, Liu B, Wang WM*, Chen G*（2023）. PD-1 Carried on small extracellular vesicles leads to OSCC metastasis. J Dent Res 102:795-805.

3. Xia HF^#, Yu ZL^#, Zhang LJ, Lin SL, Zhao Y, Huang J, Fu DD, Xie QH, Liu HM, Zhang ZL, Zhao YF, Wu M, Zhang W*, Pang DW*, Chen G*（2023）. Real-time dissection of the transportation and miRNA-release dynamics of small extracellular vesicles. Adv Sci 10:e2205566.

4. Xiao BL^#, Wang XL^#, Xia HF, Zhang LZ, Wang KM, Chen ZK, Zhong YH, Jiang HG, Zhou FX, Wang W, Chen GL, Chen G*（2023）. HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti-PD-1 treatment efficacy. Cancer Immunol Res 11:228-240.

5. Xu R^#, Yu ZL^#, Liu XC, Xie QH, Wu M*, Chen G*（2023）. Aptamer-assisted traceless isolation of PD-L1-positive small extracellular vesicles for dissecting their subpopulation signature and function. Anal Chem 95:1016-1026.

6. Yu ZL^#, Liu XC^#, Wu M, Shi S, Fu QY, Jia J*, Chen G*（2022）. Untouched isolation enables targeted functional analysis of tumour-cell-derived extracellular vesicles from tumour tissues. J Extracell Vesicles 11:e12214.

7. Yu ZL#, Zhao Y#, Miao F, Wu M, Xia HF, Chen ZK, Liu HM, Zhao YF, Chen G*（2021）. In situ membrane biotinylation enables the direct labeling and accurate kinetic analysis of small extracellular vesicles in circulation. Anal Chem 93:10862-10870.

8. Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu ZL, Yang JG, Wang BK, Sun HH, Xia HF, Man QW, Zhong WQ, Antelo LF, Wu B, Xiong XP, Liu XM, Guan L, Li T, Liu SJ, Yang RF, Lu YT, Dong LY, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu YL, Kim JY, Chen YH, Dong HD, Zhao YF, Karakousis GC, Gangadhar TC, Schuchter LM, Herlyn M, Wherry EJ, Xu XW*, Guo W*（2018）. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 Response. Nature 560:382-386.