Research

Cholesterol metabolism and metabolic diseases

Representative Publications

1. Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J and Song BL* (2022). Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature 608:413-420.

2. Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W and Song BL* (2020). Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis. Nature 588:479-484.

3. Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT* and Song BL* (2018). A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science 360:1087-1092.

4. Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL and Song BL* (2015). Cholesterol transport through lysosome-peroxisome membrane contacts. Cell 161:291-306.

5. Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL, Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW* and Song BL* (2017). Cholesterol modification of Smoothened is required for hedgehog signaling. Molecular Cell 66:154-162.