Research

1. Inter-organ communications of different metabolic tissues.

2. Epigenetic regulatory mechanisms of the transgenerational or intergenerational metabolic diseases.

Representative Publications

1. Yuan Y, Fan Y, Zhou Y, Qiu R, Kang W, Liu Y, Chen Y, Wang C, Shi J, Liu C, Li Y, Wu M, Huang K, Liu Y, Zheng L* (2023). Linker histone variant H1.2 is a brake on white adipose tissue browning. Nature Communications 14(1):3982.

2. Yang C#, Xu H#, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB, Chen H*, Huang K*, Zheng L* (2023). A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Nature Communications 14(1):4261

3. Chen H, Liu C, Wang Q, Xiong M, Zeng X, Yang D, Xie Y, Su H, Zhang Y, Huang Y, Chen Y, Yue J, Liu C, Wang S, Huang K*, Zheng L* (2022). Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver. Nature Communications 13(1):3835.

4. Sun Y, Wang Q, Zhang Y, Geng M, Wei Y, Liu Y, Liu S, Petersen RB, Yue J, Huang K*, Zheng L* (2020). Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. Journal of Hepatology 73(3):603-615.

5. Li J, Huang J, Li JS, Chen H, Huang K*, Zheng L* (2012). Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. Journal of Hepatology 56(4):900-907.