FACULTY

Hai-Bing Zhou

Final Degree:Ph.D.

Professional Title:Professor

Major:Medicinal Chemistry

Research Direction:Targeted anticancer and antiviral drug discovery

Email:zhouhb[at]whu.edu.cn

Tel:+86-027-68759586

Detailed Introduction

Research

Innovative drug discovery based on the structure and mechanism of action of biological targets, with a focus on diversity-oriented small molecule inhibitors and targeted protein degradation (TPD) agents.

Representative Publications

  1. Wang Y, Min J, Deng X, Feng T, Hu H, Guo X, Cheng Y, Xie B, Yang Y, Chen CC, Guo RT*, Dong C*, Zhou HB* (2023). Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer. Acta Pharmaceutica Sinica B 13:4963-4982.

  2. Deng X, Deng X, Ning W, Xin L, Li Q, Hu Z, Xie B, Liang K, Min C, Dong C*, Huang J*, Zhou HB* (2023). Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. Journal of Medicinal Chemistry 66:11094-11117.

  3. Xie B, Yin Z, Hu Z, Lv J, Du C, Deng X, Huang Y, Li Q, Huang J*, Liang K*, Zhou HB*, Dong C* (2023). Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-resistant Breast Cancer In Vitro and In Vivo. Journal of Medicinal Chemistry 66:6631–6651.

  4. Shen K, Yu H, Xie B, Meng Q*, Dong C*, Shen K*, Zhou HB* (2023). Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression. Pharmacology & Therapeutics 242:108350.

  5. Ning WT, Hu ZY, Tang C, Yang L, Zhang SL, Dong C, Huang J, Zhou HB* (2018). Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. Journal of Medicinal Chemistry 61:8155-8173.

  6. Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA*, Zhou HB*, Nettles KW* (2016). Predictive Features of Ligand-Specific Signaling through the Estrogen Receptor. Molecular Systems Biology 12:864.

  7. Han X, Sun N, Wu H, Guo D, Tien P, Dong C, Wu S*, Zhou HB* (2016). Identification and Structure–Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors. Journal of Medicinal Chemistry 59:2139-2150.

  8. Tang C, Li C, Zhang S, Hu Z, Wu J, Dong C*, Huang J*, Zhou HB* (2015). Novel Bioactive Hybrid Compounds Dual Targeting Estrogen Receptor and Histone Deacetylase for Treatment of Breast Cancer. Journal of Medicinal Chemistry 58:4550-4572.


Pre:Ying Zhang

Next:Yufeng Zhang