Addingto theSTING.

• ¹Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430072, China. Electronic address: shuh@whu.edu.cn.
• ²State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address: wangyy@wh.iov.cn.

STING(also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination ofSTING(MITA) by the ER-associated E3 ligase AMFR is essential forSTING(MITA)-mediated signaling and innate antiviral response.