学习经历

1999-2003 武汉大学生命科学学院，学士

2004-2010 武汉大学生命科学学院，博士；导师：付向东教授

工作经历与任职

2011-2017 美国加州大学圣地亚哥分校医学院细胞与分子医学系，博士后；导师：付向东教授

2017至今 武汉大学医学研究院，教授/博导

2020至今 武汉大学免疫与代谢前沿科学中心，PI

2022至今 武汉大学泰康生命医学中心，PI

研究领域

RNA结合蛋白不仅具有经典的RNA代谢调控功能，还能通过与染色质相互作用直接参与基因转录调控，其突变或异常表达往往会引起多种人类疾病，但机制尚不清楚。本实验室通过研发和应用功能基因组学新技术、多维智能数据挖掘和细胞与动物模型来系统研究RNA结合蛋白的分子功能与病理机制。

获奖与荣誉

国家“万人计划”青年拔尖人才（2021）

湖北省“百人计划”（2020）

湖北省“楚天学者”特聘教授（2019）

代表性论文

1. Du, X.#, Qin W.#, Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., Zhou, H., Li, S., He, F., Tang, J., Chen, J., Zhou, Y., Xiao, R.* (2024) RBM22 Regulates RNA Polymerase II 5' Pausing, Elongation Rate and Termination by Coordinating 7SK-P-TEFb complex and SPT5. Genome Biology (in press)

2. Ren, F., Miao, R., Xiao, R.*, Mei, J.* (2021) m6A reader Igf2bp3 enables germ plasm assembly by m6A-dependent regulation of gene expression in zebrafish. Science Bulletin 66: 1119-1128.

3. Du, X., Xiao, R.* (2020) An emerging role of chromatin-interacting RNA-binding proteins in transcription regulation. Essays in Biochemistry 64 (6): 907–918.

4. Van Nostrand, E.#, Freese, P.#, Pratt, G.#, Wang, X.#, Wei, X.#, Xiao, R.#, Blue, S., Chen, J., Cody, N., Dominguez, D., Olson, S., Sundararaman, B, Zhan, L., Bazile, C., Bouvrette, L., Bergalet, J., Duff, M., Garcia, K., Gelboin-Burkhart, C., Hochman, M., Lambert, N., Li, H., Nguyen, T., Palden, T., Rabano, I., Sathe, S., Stanton, R., Su, A., Wang, R., Yee, B., Zhou, B., Louie, A., Aigner, S., Fu, XD*, Lécuyer, E.*, Burge, C.*, Graveley, B.*, Yeo, G.* (2020) A Large-Scale Binding and Functional Map of Human RNA Binding Proteins. Nature 583: 711-719.

5. The ENCODE Project Consortium et al. (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature 583: 699–710.

6. The ENCODE Project Consortium et al. (2020) Perspectives on ENCODE. Nature 583: 693–698.

7. Li, Y., Xia, L., Tan, K., Ye, X., Zou, Z., Li, M., Xiao, R., Wang, Z., Liu, X., Deng, M., Cui, J., Yang, M., Luo, Q., Liu, S., Cao, X., Zhu, H., Liu, T., Hu, J., Shi, J., Xiao, S.*, Xia, L.*(2020) N(6)-methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2. Nature Genetics 52: 870-877.

8. Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.*, Mei, J.* (2020). Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebrafish. Communications Biology 3, 94.

9. Xiao, R.#*, Chen, JY#, Liang, Z#, Luo, D., Chen, G., Lu, Z., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lecuyer, E., Graveley, B., Yeo, G., Burge, C., Zhang, M., Zhou, Y. and Fu, XD* (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription. Cell. 178(1):107-121.

10. Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., and Fu, XD (2017) R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters. Molecular Cell. 68(4): 745-57.

11. Wei, C.#, Xiao, R.#, Chen, L.#, Cui, H.#, Zhou, Y.#, Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L. and Fu, XD (2016) RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell. 62(6):875-889.

12. Wang, L.#, Zhou, Y.#, Xu, L.#, Xiao, R.#, Lu, X., Chen, L., Chong, J., He, C., Fu, XD* and Wang, D*. (2015) Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 523(7562):621-625.

13. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B. and Fu, XD (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 153(4):855-68.

14. Xiao, R.*, Tang, P.*, Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. and Fu, XD (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell. 45(5):656-668.