科学研究
A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA
2024-11-12A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression
2024-11-07Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia
2024-10-01Rapid generation of long, chemically modified pegRNAs for prime editing
2024-09-30Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale
2024-07-25Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing
2024-05-24USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy
2024-04-10UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
2024-03-21Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
2024-03-16Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis
2024-02-29Fast and sensitive CRISPR detection by minimized interference of target amplification
2024-02-08Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115
2024-01-24EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses
2024-01-22Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease
2024-01-02m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3
2023-12-21
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