学习经历

1999-2003 武汉大学生命科学学院生物技术专业 学士

2003-2009武汉大学生命科学学院病毒学专业 博士

2005-2006 芬兰赫尔辛基大学生物技术专业 联合培养博士

工作经历与任职

2009-2011 武汉大学生命科学学院，生物技术系讲师

2011-2016 武汉大学生命科学学院，副教授

2016-至今 武汉大学生命科学学院，教授、病毒系副系主任

研究方向

长期从事RNA病毒蛋白的结构功能及抗病毒研究。揭示了RNA m5C甲基转移酶NSUN2在多种病毒感染过程中负调节I型干扰素反应的重要功能；解析了SARS冠状病毒RNA甲基转移酶、主蛋白酶、N蛋白等的功能、结构及其作用机制，开发了4种靶向抗冠状病毒抑制剂；系统研究了SARS、MERS及新冠病毒亚基因组特性及其复制转录机制。在本次新冠病毒疫情中，合作完成了病原鉴定，并于2020年1月7日完成全基因组测序并依规上报；鉴定了气溶胶新型冠状病毒载量及传播特性；发展了基于数字PCR的高灵敏度的核酸检测方法，建立了临床辅助诊断实验室；发表了新冠患者BALF和PBMC转录组数据，揭示了免疫及炎症反应特点；转化了1种抗新冠病毒药物等。

获奖与荣誉

教育部“CJ学者”特岗教授（2020）

湖北“向上向善”好青年（2020）

湖北省杰出青年（2018）

代表性论文

1. Feng J#, Xu T#, He M, Li J, Yao P, Ma C, Yang S, Xu Z, Yan K, Chen X, Wang H, Liu J, Zeng C, Xia Y, Yan H, Zhou L*, Chen Y*（2023）. NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication. PLoS Pathog. 19(12):e1011808.

2. Liu Q#, Zhao H#, Li Z#, Zhang Z#, Huang R#, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y*, Yan H*, Cao S*, Lan K*, Chen Y*（2023）. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther. 8(1):347.

3. Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y*（2023）. NSUN2-mediated M5c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections. Emerg Microbes Infect. 12(1):2178238.

4. Pan R#, Kindler E#, Cao L#, Zhou Y, Zhang Z, Liu Q, Ebert N, Züst R, Sun Y, Gorbalenya AE, Perlman S*, Thiel V*, Chen Y*, Guo D*（2022）. N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition. mBio.13(1):e0366221.

5. Ma C#, Chen X#, Mei F#, Xiong Q, Liu Q, Dong L, Liu C, Zou W, Zhan F, Hu B, Liu Y, Liu F, Zhou L, Xu J, Jiang Y, Xu K, Cai K*, Chen Y*, Yan H*, Lan K*（2022）. Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 11(1):567-572.

6. Liu Q#, Xiong Q#, Mei F#, Ma C, Zhang Z, Hu B, Xu J, Jiang Y, Zhan F, Zhou S, Tao L, Chen X, Guo M, Wang X, Fang Y, Shen S, Liu Y, Liu F, Zhou L, Xu K, Ke C, Deng F, Cai K*, Yan H*, Chen Y*, Lan K*（2022）. Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China. Innovation (N Y). 3(1):100181.

7. Zhang Z#, Liu Q#, Sun Y, Li J, Liu J, Pan R, Cao L, Chen X, Li Y, Zhang Y, Xu K, Guo D, Zhou L, Lan K, Chen Y*（2021）. Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice. Emerg Microbes Infect. 10(1):1626-1637.

8. Yan H#, Jiao H#, Liu Q, Zhang Z, Xiong Q, Wang BJ, Wang X, Guo M, Wang LF, Lan K*, Chen Y*, Zhao H*（2021）. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature ecology & evolution. 5(5):600-608. .

9. Wang D#, Jiang A#, Feng J#, Li G#, Guo D#, Sajid M, Wu K, Zhang Q, Ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K*, Chen Y*, Zhou Y*（ 2021）. The SARS-CoV-2 subgenome landscape and its novel regulatory features. Molecular cell.81(10):2135-2147.

10. Yan K, Feng J, Liu X, Wang H, Li Q, Li J, Xu T, Sajid M, Ullah H, Zhou L, Zhou L*, Chen Y*（2021）. Inhibition of Hepatitis B Virus by AAV8-Derived CRISPR/SaCas9 Expressed From Liver-Specific Promoters. Frontiers in microbiology. 12:665184..

11. Liu Y#, Ning Z#*, Chen Y#*, Guo M#, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, Liu X, Xu K, Ho KF*, Kan H*, Fu Q*, Lan K*（2020）. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. 582(7813):557-560.

12. Xiong Y#, Liu Y#, Cao L#, Wang D#, Guo M, Jiang A, Guo D, Hu W, Yang J, Tang Z, Wu H, Lin Y, Zhang M, Zhang Q, Shi M, Liu Y, Zhou Y*, Lan K*, Chen Y*(2020). Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerg Microbes Infect. 9(1):761-770.

13. Chen L#, Liu W#, Zhang Q#, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y*, Li Y*, Shi M*, Lan K*, Liu Y*(2020). RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect. 9(1):313-329.

14. Suo T#, Liu X#, Feng J#, Guo M#, Hu W#, Guo D, Ullah H, Yang Y, Zhang Q, Wang X, Sajid M, Huang Z, Deng L, Chen T, Liu F, Xu K, Liu Y, Zhang Q, Liu Y, Xiong Y*, Chen G*, Lan K*, Chen Y*(2020). ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens. Emerg Microbes Infect. 9(1):1259-1268.

15. Liu X#, Feng J#, Zhang Q#, Guo D#, Zhang L, Suo T, Hu W, Guo M, Wang X, Huang Z, Xiong Y, Chen G*, Chen Y*, Lan K*(2020). Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets. Emerg Microbes Infect. 9(1):1175-1179.

16. Chen Y*, Liu Q, Guo D*(2020). Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Med Virol. 92(4):418-423.

17. Cao L, Ji Y, Zeng L, Liu Q, Zhang Z, Guo S, Guo X, Tong Y, Zhao X, Li CM, Chen Y*, Guo D*(2019). P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus. PLoS Pathog. 15(10):e1008079.