Immunity.2014 Dec 18;41(6):871-3. doi: 10.1016/j.immuni.2014.12.002.
Addingto theSTING.
- 1Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430072, China. Electronic address: shuh@whu.edu.cn.
- 2State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430072, China. Electronic address: wangyy@wh.iov.cn.
Abstract
STING(also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination ofSTING(MITA) by the ER-associated E3 ligase AMFR is essential forSTING(MITA)-mediated signaling and innate antiviral response.
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