教育经历

2001-2005 北京大学生命科学学院生物科学专业，学士

2005-2010 北京大学生命科学学院细胞生物学专业，博士

工作经历与任职

2011-2012 美国霍华德休斯医学研究所及北卡罗莱纳大学教堂山分校，博士后

2012-2015 美国霍华德休斯医学研究所及哈佛医学院、波士顿儿童医院，博士后

2015- 武汉大学医学研究院教授、中南医院特聘研究员

研究兴趣

干细胞分化，表观遗传学调控，长非编码RNA，疾病模型，糖尿病

本实验室的长期兴趣是结合发育生物学和遗传学/表观遗传学的基础研究，应用于多能干细胞分化模型来揭示疾病发生的分子机制，关注点是组蛋白修饰、长非编码RNA以及细胞代谢层面的细胞命运决定的分子调控；同时以此获得功能性细胞用于再生医学。研究手段主要包括人多能干细胞建立和维持、定向诱导分化（内胚层和胰腺方向），基因组编辑以及组织工程。目前受国家自然科学基金委重大研究计划培育项目和面上项目、科技部重点研发专项项目支持。

获奖、荣誉、学术兼职

HMS Epigenetics Initiative Travel Grant (2015);

Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015);

Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013);

Science Bulletin 青年编委（2019-）

杂志审稿人： Cell Reports, Stem Cells, Seminars in Cell and Developmental Biology, Stem Cell Research, Tissue Engineering, Stem Cells and Development, Stem Cells Translational Medicine, Experimental Cell Research, Stem Cell Reviews and Reports, Cellular Reprogramming, Journal of Diabetes Research, Molecular and Cellular Biochemistry, Stem Cell International

发表论文概况

已在国际刊物发表论文50多篇，被SCI引用2000余次，主要作者论文单篇最高被引用400余次。

代表性论文（34 out of 50+ ）（# co-first authors；*co-responding authors）

1. Songwei Wang#, Yangyang Yu#, Yinglei Li, Tianzhe Zhang, Wei Jiang*, Xinghuan Wang*, Ran Liu*. (2 Sep 2024). Prostate lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1. Stem Cell Research & Therapy. 15:274. DOI: 10.1186/s13287-024-03886-y.

2. Lai Jiang, Chenchao Yan, Ying Yi, Lihang Zhu, Zheng Liu, Donghui Zhang*, Wei Jiang*. (13 Aug 2024). Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling. Stem Cell Reports. 19(8):1137-1155. DOI: 10.1016/j.stemcr.2024.07.001.

3. Liwen Jiang, Linfeng Huang*, Wei Jiang*. (4 Jul 2024). H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation. Cell Insight. 3(4):100180. DOI: 10.1016/j.cellin.2024.100180.

4. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. (25 Sep 2023). Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell. 58(18):1670-1687. DOI: 10.1016/j.devcel.2023.07.005.

5. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. (24 Apr 2023). A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology. 24(1):92. DOI: 10.1186/s13059-023-02925-w.

6. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. (15 Mar 2023). Translational landscape in human early neural fate determination. Development. 150 (6): dev201177. DOI: 10.1242/dev.201177.

7. Li Li#, Zhongjun Wan#, Ruxiang Wang, Yuxin Zhao, Yida Ye, Pengcheng Yang, Yan Qi, Wei Jiang*, Lin Cai*, Donghui Zhang*. (11 Oct 2022). Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells. Cell Discovery. 8:105. DOI: 10.1038/s41421-022-00446-7.

8. Wenwen Jin, Wei Jiang*. (23 Aug 2022). Stepwise differentiation of human pluripotent stem cells into functional pancreatic β cells. Cell Regeneration. 11(1):24. DOI: 10.1186/s13619-022-00125-8.

9. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. (6 Aug 2022). PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications. 13(1):4601. DOI: 10.1038/s41467-022-32295-z.

10. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. (20 May 2022). Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research. 50(9): 4959-4973. DOI: 10.1093/nar/gkac265.

11. Fang Xie#, Lai Jiang#, Ximian Xiao#, Yiwen Lu, Runhui Liu*, Wei Jiang*, Jie Cai*. (24 Mar 2022). Quaternized polysaccharide-based cationic micelles as a macromolecular approach to eradicate multidrug-resistant bacterial infections while mitigating antimicrobial resistance. Small. 18(12):e2104885. DOI: 10.1002/smll.202104885.

12. Jing Lv#, Ying Yi#, Yan Qi, Chenchao Yan, Wenwen Jin, Liming Meng, Donghui Zhang*, Wei Jiang*. (17 Feb 2022). Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells. Cell Death & Discovery. 8:69. DOI: 10.1038/s41420-022-00867-z.

13. Yan Qi#, Yida Ye#, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang*, Yifei Li*, Donghui Zhang*. (22 Jan 2022). Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biology. 50:102248. DOI: 10.1016/j.redox.2022.102248.

14. Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang*, Wei Jiang*. (3 Jan 2022). Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies. Theranostics. 12(4):1537-1556. DOI: 10.7150/thno.66670.

15. Song Ding#, Xianchun Lan#, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li*, Jian Chen*, Wei Jiang*. (22 Oct 2021). CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis. Cell Death & Disease. 12(11):981. DOI: 10.1038/s41419-021-04292-5.

16. Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Yingan Jiang*, Wei Jiang*. (8 Sep 2021). Depletion of demethylase KDM6 enhances early neuroectoderm commitment of human PSCs. Frontiers in Cell and Developmental Biology. 9:702462. DOI: 10.3389/fcell.2021.702462.

17. Ran Zheng#, Ting Geng#, Dan-Ya Wu#, Tianzhe Zhang, Hainan He, Hai-Ning Du, Donghui Zhang*, Yi-Liang Miao*, Wei Jiang*. (13 Jul 2021). Derivation of feeder-free human extended pluripotent stem cells. Stem Cell Reports. 16(7):1686-1696. DOI: 10.1016/j.stemcr.2021.06.001.

18. Pei Lu#, Mao Li#, Donghui Zhang*, Wei Jiang*. (22 Mar 2021). Lnc-ing pluripotency maintenance and early differentiation in human pluripotent stem cells. FASEB Journal 35(4): e21438. DOI: 10.1096/fj.202002278R.

19. Ran Liu#, Kaiyu Qian#, Yu Xiao*, Wei Jiang*. (18 Mar 2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research. 53:102299. DOI: 10.1016/j.scr.2021.102299.

20. Jie Yang#, Pei Lu#, Mao Li, Chenchao Yan, Tianzhe Zhang, Wei Jiang*. (13 Aug 2020). GATA6-AS1 regulates GATA6 expression to modulate human endoderm differentiation. Stem Cell Reports 15(3):694-705. DOI: 10.1016/j.stemcr.2020.07.014.

21. Jie Yang, Wei Jiang*. (21 July 2020). The roles of SMAD2/3 in human embryonic stem cells. Frontiers in Cell and Developmental Biology 8:653. DOI: 10.3389/fcell.2020.00653. 入选Editor’s Pick 2021: Highlights in Stem Cell Research

22. Yangyang Yu, Wei Jiang*. (16 Jul 2020). Pluripotent stem cell differentiation as an emerging model to study human prostate development. Stem Cell Research & Therapy. 11(1):285. DOI: 10.1186/s13287-020-01801-9.

23. Mengtian Tan, Lai Jiang, Yinglei Li, Wei Jiang*. (1 Dec 2019). Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells. Stem Cells International. 2019(5026793):1-15. DOI: 10.1155/2019/5026793.

24. Ting Geng, Donghui Zhang, Wei Jiang*. (Nov 2019). Epigenetic regulation of transition among different pluripotent states. Stem Cells. 37(11):1372-1380. DOI: 10.1002/stem.3064.

25. Yinglei Li, Wei Jiang*. (30 Aug 2019). The path and surface marker of SC-β cells. Science Bulletin. 64(16): 1122-1124. DOI: 10.1016/j.scib.2019.06.018.

26. Xiaojuan Su#, Mengtian Tan#, Bo Duan, Jie Cai*, Wei Jiang*, Lina Zhang*. (28 Aug 2019). Hierarchical microspheres with macropores fabricated from chitin as 3D cell culture. Journal of Materials Chemistry B. 7(34), 5190-5198. DOI: 10.1039/c9tb01046g.

27. Wei Jiang*, Yuting Liu, Rui Liu, Kun Zhang, Yi Zhang*. (7 Apr 2015). LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 11(1), 137-148. DOI: 10.1016/j.celrep.2015.03.008.

28. Donghui Zhang*, Wei Jiang*. (28 Feb 2015). From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 65 (5): 468-475. DOI: 10.1093/biosci/biv016.

29. Wei Jiang*, Donghui Zhang, Nenad Bursac, Yi Zhang*. (4 Jun 2013). WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 (1), 46-52. DOI: 10.1016/j.stemcr.2013.03.003.

30. Wei Jiang, Jinzhao Wang, Yi Zhang*. (21 Aug 2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 23(1), 122-130. DOI: 10.1038/cr.2012.119.

31. Wei Jiang#, Xin Sui#, Donghui Zhang, Meng Liu, Mingxiao Ding, Yan Shi*, Hongkui Deng*. (2011). CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 29(4):609-617. DOI: 10.1002/stem.608.

32. Donghui Zhang#, Wei Jiang#, Meng Liu, Xin Sui, Xiaolei Yin, Song Chen, Yan Shi, Hongkui Deng*. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 19(4):429-438. DOI: 10.1038/cr.2009.28.

33. Wei Jiang#, Zhaodai Bai#, Donghui Zhang, Yan Shi, Jun Yong, Song Chen, Mingxiao Ding, Hongkui Deng*. (2008). Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 51:1671-1679. DOI: 10.1007/s00125-008-1065-1.

34. Wei Jiang#, Yan Shi#, Dongxin Zhao, Song Chen, Jun Yong, Jing Zhang, Tingting Qing, Xiaoning Sun, Peng Zhang, Mingxiao Ding, Dongsheng Li*, Hongkui Deng*. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 17:333-344. DOI: 10.1038/cr.2007.28.