学习经历
2004.9--2008.6 理学学士 武汉大学生命科学学院生物学专业
管理学学士 武汉大学经济管理学院（第二学位）
2008.9--2013.6 理学博士 武汉大学生命科学学院细胞生物学专业
工作经历与任职
2013.6--2015.5 师资博士后 武汉大学生命科学学院
2015.5--2017.11 讲 师 武汉大学生命科学学院
2016.2--2017.8 博士后 MD Anderson Cancer Center, USA
2017.11--2022.11 副教授 武汉大学生命科学学院
2022.11-- 教 授 武汉大学生命科学学院
2023.06-- 兼职研究员 免疫与代谢前沿科学中心
研究方向
病毒与宿主互作
获奖与荣誉
2024 武汉大学本科优秀教学业绩奖
2023 武汉大学青年教师教学比赛二等奖
2022 国家级高层次人才（青年项目入选者）
2021 湖北省青年拔尖人才
2015 国家自然科学奖二等奖(排名第五)
2015 湖北省科技晨光计划
2014 教育部自然科学奖一等奖(排名第五)
2014 湖北省优秀博士论文奖
2011 吴瑞奖
2011 教育部学术新人奖
代表性论文
1. Xu Yanran#, Shi Mengling#, Zhang Yu#, Kong Na, Wang Cong, Xiao Yifeng, Du Shishen, Zhu Qiyun, Lei Caoqi*. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation. PNAS, 2022, doi.org/10.1073/pnas.2122805119.
2. Zeng Yan, Xu Shuai, Wei Yanli, Zhang Xuefeng, Wang Qian, Jia Yane, Wang Wanbing, Han Lu, Chen Zhaoshan, Wang Zhengxiang, Zhang Bo, Chen Hualan, Lei Caoqi*, Zhu Qiyun*. The PB1 Protein of Influenza A Virus Inhibits the Innate Immune Response by Targeting MAVS for NBR1-Mediated Selective Autophagic Degradation. PLoS Pathogens, 2021. doi.org/10.1371/journal.ppat.1009300
3. Xu Yanran#, Lei Caoqi*. TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses. Frontiers in Immunology, 2021. doi.org/10.3389/fimmu.2020.608976
4. Wei Yanli#, Zeng Yan#, Zhang Xuegang, Xu Shuai, Wang Zhengxiang, Du Yingying, Zhang Bo, Lei Caoqi*, Zhu Qiyun*. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. Journal of Virology, 2020, 23;94(24):e01640-20
5. Zhong Xuan#, Feng Lu, Xu Wenhua, Wuxin, Ding Yidi, Zhou Yan, Lei Caoqi*, Shu Hongbing*. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating its ligand binding. Cellular & Molecular Immunology, 2020, 17(7):741-752.
6. Lei Caoqi#*, Wu Xin#, Zhong Xuan, Jiang Lu, Zhong Bo, Shu Hongbing*. USP19 inhibits TNFa- and IL-1b-triggered NF-kB activation by deubiquitinating TAK1. Journal of Immunology, 2019, 203(1):259-268.
7. Chen Zhen#, Lei Caoqi#, Wang Chao, Li Nan, Mrinal Srivastava, Tang Mengfan, Zhang Huimin, Choi Jongmin, Jung Sungyun, Qin Jun, Chen Junjie*. Global Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics. Nature Communications, 2019, 10: 104
8. Wang Junyong#, Zeng Yan, Xu Shuai, Yang Jiayun, Wang Wanbing, Ge Jinying, Yin Lei, Wang Zhengxiang, Han Lu, Cui Xiaole, Zhong Bo, Shu Hongbing, Chen Hualan, Lei Caoqi*, Zhu Qiyun*, A naturally occurring deletion in the effector domain of H5N1 influenza virus nonstructural protein 1 regulates viral fitness and host innate immunity. Journal of Virology, 2018, 92(11): e00149-18
9. Wang Junyong#, Lei Caoqi*, Ji Yanhong, Zhou Hongbo, Ren Yujie, Peng Qianqian, Zeng Yan, Jia Yane, Ge Jinying, Zhong Bo, Li Yu, Wei Jianzhong, Shu Hongbing, Zhu Qiyun*, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA. Journal of Immunology, 2016, 197(12):4704-4713.
10. Lei Caoqi#, Zhang Yu, Li Mi, Jiang Liqun, Zhong Bo, Kim Yonghao, Shu Hongbing*, ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses. Journal of Innate Immunity, 2015, 7(2):153-164.
11. Lei Caoqi#, Zhang Yu, Xia Tian, Jiang Liqun, Zhong Bo, Shu Hongbing*, FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. Journal of Biological Chemistry, 2013, 288(18):12596-12604.
12. Lei Caoqi#, Zhong Bo, Zhang Yu, Zhang Jing, Wang Shuai, Shu Hongbing*， Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity, 2010, 33(6):878-889.
