学习经历

1995.9－1999.6 北京大学生命科学学院，本科生，获学士学位

1999.9－2004.6 北京大学生命科学学院，硕博连读研究生，获博士学位

2001.3－2002.6 美国国立犹太医学研究中心，交换学生

工作经历与任职

2004.9－2007.3 耶鲁大学医学院，博士后

2007.4－2009.2 美国Stowers医学研究所，博士后

2009.3至今 武汉大学生命科学学院，教授，博士生导师

2021.1至今 武汉大学生命科学学院生物化学系主任

研究方向

肿瘤表观遗传、炎癌转化

获奖与荣誉

2022 乳腺癌基因诊断指导精准治疗关键技术创新与应用，湖北省科技进步二等奖，第四完成人（张京伟; 魏蕾; 周海兵; 吴旻; 何春江; 国世上; 敖英; 田毅浩; 高阳; 张尊）

2016 武汉大学生命科学学院“双一流”特聘教授

2010 细胞凋亡与抗病毒反应的信号转导研究，国家自然科学二等奖，第四完成人（舒红兵; 翟中和; 陈丹英; 吴旻; 卢智刚）

2010 湖北省“楚天学者”计划楚天学子教授

2006 北京大学优秀博士论文二等奖

2006 细胞凋亡与NF-kappaB激活的信号传导研究，教育部科学技术奖一等奖，第四完成人 （舒红兵; 翟中和; 陈丹英; 吴旻; 赵允; 黄俊; 孙英丽; 蒋争凡; 卢智刚）

代表性论文

(1) Zheng, Y., Zhao, C., Song, Q., Xu, L., Zhang, B., Hu, G., Kong, X., Li, S., Li, X., Shen, Y., Zhuang, L., Wu, M.*, Liu, Y.*, and Zhou, Y.*, Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep, 2023. 42(12): p. 113496.

(2) Zhang, L.Y., Wang, C.Y., Xu, Q., Mu, Z.Q., Lin, X., Li, L.Y., Xiao, Y., Wu, M.*, and Chen, M.K.*, Removal of epigenetic repressive mark on inflammatory genes in fat liver. Journal of Gastroenterology and Hepatology, 2023. 38(8): p. 1426-1437.

(3) Lin, X., Chen, J.D., Wang, C.Y., Cai, Z., Zhan, R., Yang, C., Zhang, L.Y., Li, L.Y., Xiao, Y.*, Chen, M.K.*, and Wu, M.*, Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer. Genome Biol, 2023. 24(1): p. 268.

(4) Xiao, Q., Wang, C.Y., Gao, C., Chen, J.D., Chen, J.J., Wang, Z., Ju, L.G., Tang, S.B., Yao, J., Li, F., Li, L.Y., and Wu, M.*, Regulation of KDM5C stability and enhancer reprogramming in breast cancer. Cell Death Dis, 2022. 13(10): p. 843.

(5) Xiao, Q., Xiao, Y., Li, L.Y., Chen, M.K.*, and Wu, M.*, Multifaceted regulation of enhancers in cancer. Biochim Biophys Acta Gene Regul Mech, 2022. 1865(6): p. 194839.

(6) Chen, L., Yang, C., Tang, S.-B., Long, Q.-Y., Chen, J.-D., Wu, M.*, and Li, L.-Y.*, Inhibition of histone methyltransferase SETD8 represses DNA virus replication. Cell Insight, 2022. 1(3).

(7) Chen, L., Luo, Z., Zhao, C., Li, Q., Geng, Y., Xiao, Y., Chen, M.K., Li, L., Chen, Z.X.*, and Wu, M.*, Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer. Adv Sci (Weinh), 2022: p. e2200536.

(8) Li, Q.L., Lin, X., Yu, Y.L., Chen, L., Hu, Q.X., Chen, M., Cao, N., Zhao, C., Wang, C.Y., Huang, C.W., Li, L.Y., Ye, M. *, and Wu, M. *, Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers. Nat Commun, 2021. 12(1): p. 6407.

(9) Hu, Q.X., Wang, H.Y., Jiang, L., Wang, C.Y., Ju, L.G., Zhu, Y., Zhong, B., Wu, M. *, Wang, Z. *, and Li, L.Y. *, Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression. PLoS Pathog, 2021. 17(9): p. e1009918.

(10) Wang, Z., Chen, J., Gao, C., Xiao, Q., Wang, X.W., Tang, S.B., Li, Q.L., Zhong, B., Song, Z.Y., Shu, H.B., Li, L.Y., and Wu, M. *, Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm. Adv Sci (Weinh), 2021: p. e2100779.

(11) Wang, C.Y., Yu, G.T., Gao, C., Chen, J., Li, Q.L., Zhang, L., Wu, M. *, Sun, Z.J. *, and Li, L.Y. *, Genome-Wide Enhancer Analysis Reveals the Role of AP-1 Transcription Factor in Head and Neck Squamous Cell Carcinoma. Front Mol Biosci, 2021. 8: p. 701531.

(12) Zheng, J.Y., Wang, C.Y., Gao, C., Xiao, Q., Huang, C.W., Wu, M. *, and Li, L.Y. *, MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity. Cell Death Dis, 2021. 12(4): p. 364.

(13) Xu, L., Zheng, Y., Li, X., Wang, A., Huo, D., Li, Q., Wang, S., Luo, Z., Liu, Y., Xu, F., Wu, X., Wu, M. *, and Zhou, Y. *, Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv, 2021. 7(1).

(14) Li, X.J., Li, Q.L., Ju, L.G., Zhao, C., Zhao, L.S., Du, J.W., Wang, Y., Zheng, L., Song, B.L., Li, L.Y., Li, L. *, and Wu, M. *, Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC. Hepatology, 2021. 73(5): p. 1797-1815.

(15) Yao J., Lei P.J., Li Q.L., Chen J., Tang S.B., Xiao Q., Lin X., Wang X., Li L.Y., Wu M.* GLIS2 promotes colorectal cancer through repressing enhancer activation. Oncogenesis 2020, 9:57.

(16) Gao C., Chen L., Tang S.B., Long Q.Y., He J.L., Zhang N.A., Shu H.B., Chen Z.X., Wu M.*, Li L.Y.* The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells. Antiviral Res 2020, 176:104730.

(17) Wang H.Y., Long Q.Y., Tang S.B., Xiao Q., Gao C., Zhao Q.Y., Li Q.L., Ye M., Zhang L., Li L.Y., Wu M.* Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer. Nucleic Acids Res 2019, 47:2349-2364.

(18) Li Q.L., Wang D.Y., Ju L.G., Yao J., Gao C., Lei P.J., Li L.Y., Zhao X.L.*, Wu M.* The hyper-activation of transcriptional enhancers in breast cancer. Clin Epigenetics 2019, 11:48.

(19) Ju L.G., Zhu Y., Long Q.Y., Li X.J., Lin X., Tang S.B., Yin L., Xiao Y., Wang X.H., Li L., Zhang L., Wu M.* SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability. Cell Death Differ 2019, 26:1156-1168.

(20) 王震，李联运*，吴旻*。表观遗传相关药物对癌症的治疗。细胞生物学报，2018;40(8):1253-1263.

(21) Zhu K., Lei P.J., Ju L.G., Wang X., Huang K., Yang B., Shao C., Zhu Y., Wei G., Fu X.D., Li L., Wu M.* SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. Nucleic Acids Res 2017, 45:92-105.

(22) Wang Z., Long Q.Y., Chen L., Fan J.D., Wang Z.N., Li L.Y.*, Wu M.*, Chen X.* Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta 2017, 1864:2428-2437.

(23) Li Q.L., Lei P.J., Zhao Q.Y., Li L., Wei G.*, Wu M.* Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation. Epigenomics 2017, 9:1077-1092.

(24) Ju L.G., Zhu Y., Lei P.J., Yan D., Zhu K., Wang X., Li Q.L., Li X.J., Chen J.W., Li L.Y.*, Wu M.* TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS. J Immunol 2017, 198:1274-1284.

(25) Jia X., Long Q., Miron R.J., Yin C., Wei Y., Zhang Y.*, Wu M.* Setd2 is associated with strontium-induced bone regeneration. Acta Biomater 2017, 53:495-505.

(26) Zhao Q.Y., Lei P.J., Zhang X., Zheng J.Y., Wang H.Y., Zhao J., Li Y.M., Ye M., Li L., Wei G.*, Wu M.* Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clin Epigenetics 2016, 8:34.

(27) Su S.K., Li C.Y., Lei P.J., Wang X., Zhao Q.Y., Cai Y., Wang Z., Li L.*, Wu M.* The EZH1-SUZ12 complex positively regulates the transcription of NF-kappaB target genes through interaction with UXT. J Cell Sci 2016, 129:2343-2353.

(28) Zhu K., Wang X., Ju L.G., Zhu Y., Yao J., Wang Y., Wu M.*, Li L.Y.* WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines. J Immunol 2015, 195:5358-5366.

(29) Fan J.D., Lei P.J., Zheng J.Y., Wang X., Li S., Liu H., He Y.L., Wang Z.N., Wei G., Zhang X., Li L.Y.*, Wu M.* The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death. PLoS One 2015, 10:e0116782.

(30) Wang X., Ju L., Fan J., Zhu Y., Liu X., Zhu K., Wu M.*, Li L.* Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. Biochim Biophys Acta 2014, 1843:2592-2602.

(31) Zhao Q., Fan J., Hong W., Li L., Wu M.* Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway. Springerplus 2012, 1:65.

(32) Wang X., Zhu K., Li S., Liao Y., Du R., Zhang X., Shu H.B., Guo A.Y., Li L.*, Wu M.* MLL1, a H3K4 methyltransferase, regulates the TNFalpha-stimulated activation of genes downstream of NF-kappaB. J Cell Sci 2012, 125:4058-4066.

(33) Wu M.*, Shu H.B.* MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer 2011, 30:240-246.

(34) Wu M. ^#, Wang P.F.^#, Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol 2008, 28:7337-7344.

(35) Higa L.A. ^#, Wu M. ^#, Ye T., Kobayashi R., Sun H., Zhang H. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 2006, 8:1277-1283.

(36) Banks D. ^#, Wu M. ^#, Higa L.A., Gavrilova N., Quan J., Ye T., Kobayashi R., Sun H., Zhang H. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle 2006, 5:1719-1729.

(37) Wu M. ^#, Xu L.G., Su T., Tian Y., Zhai Z., Shu H.B. AMID is a p53-inducible gene downregulated in tumors. Oncogene 2004, 23:6815-6819.

(38) Wu M. ^#, Xu L.G., Zhai Z., Shu H.B. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J Biol Chem 2003, 278:27072-27079.

(39) Xu L.G. ^#, Wu M. ^#, Hu J., Zhai Z., Shu H.B. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J Leukoc Biol 2002, 72:410-416.

(40) Wu M.^#, Xu L.G.^#, Li X., Zhai Z., Shu H.B. AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem 2002, 277:25617-25623.

(41) Wu M. ^#, Zhao Y. and Zhai Z. The ultrastructural observation of apoptotic mouse liver cell nuclei. Journal of Chinese Electron Microscopy Society 2001, Vol. 20, No.1, 21-26.