学习经历
1982-1986 武汉大学病毒学及分子生物学系,学士
1986-1989 武汉大学病毒学及分子生物学系病毒生化专业,硕士
1993-1997 香港科技大学生物化学系, 博士
工作经历与任职
1989-1993 湖北医科大学微生物及免疫学教研室 讲师
1997-09 至 2001-10, 美国马里兰大学, College Park博士后和Research specialist
2001-10 至 2002-05, 武汉大学, 基础医学院,微生物及免疫学教研室, 教授
2002-05-至今 武汉大学基础医学院免疫学系,教授、系主任
2004-09 至 2004-12, 日本福岛医科大学, 免疫学系, 研究员
2004-10 至 今, 武汉大学, 病毒学国家重点实验室, 教授
2017-06 至 今, 武汉大学, 医学研究院和免疫与代谢前沿研究中心, 兼职教授
研究方向
病原微生物糖生物学与感染免疫
获奖与荣誉
国家杰出青年科学基金获得者(2010)
代表性论文
1. Pan Q; Xie Y; Zhang Y; Guo X; Wang J; Liu M*; Zhang X-L* (2024) EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses, Nature Communications, 15(1): 652
2. Yao Q; Xie Y; Xu D; Qu ZL; Wu J; Zhou YY; Wei YY; Xiong H; Zhang X-L* (2022) Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3, Cellular & Molecular Immunology, 19(8): 883-897
3. Qu Z; Zhou J; Zhou Y; Xie Y; Jiang Y; Wu J; Luo Z; Yin Le*; Zhang X-L* (2020) Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway., Science Advances, 6(43): eaba4733
4. Bian WX#, Xie Y#, Wang XN, Xu GH, Fu BS, Li S, Long G, Zhou X*, Zhang X-L* (2019) Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication. Nucleic Acids Res, 47(1):56-68.
5. Sun X; Pan Q; Yuan C; Wang Q; Tang XL; Ding K; Zhou X; Zhang X-L** (2016) A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guerin Enhances Immunoprotective Effect against Tuberculosis, Journal of the American Chemical Society, 138(36): 11680-11689
6. Wang SR#, Min YQ#, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T*, Zhang XL*, Zhou X* (2016) A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2(4): e1501535.