学习经历
1997-2001 山东师范大学生物系生命科学专业, 学士
2001-2004 中国科学院动物研究所细胞生物学专业, 硕士
2008-2012 美国马萨诸塞大学医学院肿瘤生物学专业, 博士
工作经历与任职
2004-2006 中科院上海药物所，助理研究员
2012-2016 美国哈佛医学院丹娜法伯癌症中心，博士后
2016-至今 武汉大学医学研究院，教授
研究方向
血液疾病、细胞治疗、表观调控
获奖与荣誉
国家杰出青年科学基金
国家高层次人才青年项目
国家自然科学基金优秀青年
哈佛大学华人学者生命科学杰出研究奖
美国Leukemia & Lymphoma Society Fellow奖
研究领域
课题组长期致力于探索血液疾病发病机制与靶向策略及免疫治疗，目前主要聚焦急性髓系白血病细胞的表观转录调控及免疫逃逸机制研究。
代表性论文
1. Cheng Y#, Gao Z#, Zhang T#, Wang Y, Xie X, Han G, Li Y, Yin R, Chen Y, Wang P, Hu J, Zhang T, Guo C, Chai J, Wang J, Cui M, Gao K, Liu W, Yao S, Lu P, Cao Z, Zheng Y, Chang J, Liu Z, Song Q, Li W, Zhou F, Zhang H*. Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promotes AML stem cell maintenance. Cell Stem Cell, 2023, 30:69-85.
2. Yin R#, Chang J#, Li Y#, Gao Z, Qiu Q, Wang Q, Han G, Chai J, Feng M, Wang P, Zhang T, Xie X, Hu J, Cheng Y, Guo C, Wang J, Gao K, Cui M, Li S, Zheng Y, Jiang W, Hu Y, Yang Q, Zhang H*. Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell, 2022, 29: 149-159.
3. Wang J#, Li Y#, Wang P#, Han G#, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, Wang Q, Hu J, Cheng Y, Zhang T, Li Y, Gao Z, Guo C, Wang J, Liang J, Cui M, Gao K, Chai J, Liu W, Cheng H, Li L, Zhou F, Liu L, Luo Y, Li S, Zhang H*. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell, 2020, 27:81-97.
4. Feng M#, Xie X#, Han G#, Zhang T, Li Y, Li Y, Yin R, Wang Q, Zhang T, Wang P, Hu J, Cheng Y, Gao Z, Wang J, Chang J, Cui M, Gao K, Chai J, Liu W, Guo C, Li S, Liu L, Zhou F, Chen J, Zhang H*. YBX1 is required for maintaining myeloid leukemia cell survival by regu lating BCL2 stability in an m6A-dependent manner. Blood, 2021, 138(1): 71-85.
5. Wang Q#, Hu J#, Han G#, Wang P, Li S, Chang J, Gao K, Yin R, Li Y, Zhang T, Chai J, Gao Z, Zhang T, Cheng Y, Guo C, Wang J, Liu W, Cui M, Xu Y, Hou J, Zhu Q, Feng Y, Zhang H*. PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation. Cell Reports, 2022, 38:110603.
6. Zhang T#, Cui M#, Li Y, Cheng Y, Gao Z, Wang J, Zhang T, Han G, Yin R, Wang P, Tian W, Liu W, Hu J, Wang Y, Liu Z*, Zhang H*. Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity. Haematologica, 2023, 108:2410-2421.
7. Zhang H, Kozono DE, O’Connor KW, Vadal-Cardnenas S, Rousseau A, Hamilton A, Moreau L, Gaudiano EF, Greenberger J, Bagby G, Soulier J, Grompe M, Pamar K, D’Andrea AD*. TGF-β inhibition rescues hematopoietic stem cel l defects and bone marrow failure in fanconi anemia. Cell Stem Cell, 2016, 18(5): 668-681
8. Zhang H, Peng C, Hu Y, Li H, Sheng Z, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Shaoguang Li*. The Blk pathway functions as a tumor suppressor in chronic mye loid leukemia stem cells. Nature Genetics, 2012, 44(8): 861-871
9. Zhang H, Li H, Ho N, Li D, Shaoguang Li*. HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood, 2012, 119(11): 2595-2607.
