学习经历

2001-2005 北京大学生命科学学院，学士

2005-2011 中国科学院微生物研究所，博士

工作经历与任职

2011-2018 美国南加州大学分子微生物与免疫学系，博士后

2018-至今 武汉大学医学研究院、病毒学国家重点实验室，教授

研究方向

以卡波氏肉瘤相关疱疹病毒(KSHV)，单纯疱疹病毒1型(HSV-1)及鼠γ疱疹病毒68(MHV68)为对象，开展下列研究：

1. 研究疱疹病毒拮抗宿主抗病毒免疫反应的分子机制

2. 鉴定调控疱疹病毒裂解再激活的关键病毒蛋白及宿主因子

3. 建立肿瘤疱疹病毒感染致瘤的小动物模型，揭示肿瘤疱疹病毒感染引起肿瘤发生发展的机理

4. 发展更有效的溶瘤疱疹病毒进行肿瘤免疫治疗

获奖与荣誉

2011 中国科学院朱李月华优秀博士毕业生奖

2016 19th International Workshop on KSHV and Related Agents Travel award

代表性论文

1. Wang S, Tian X, Zhou Y, Xie J, Gao M, Zhong Y, Zhang C, Yu K, Bai L, Qin Q, Zhong B, Lin D, Feng P, Lan K, Zhang J*. (2024) Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases. PLoS Pathogens 20(1): e1011943.

2. Zhang L, Jiang C, Zhong Y, Sun K, Jing H, Song J, Xie J, Zhou Y, Tian M, Zhang C, Sun X, Wang S, Cheng X, Zhang Y, Wei W, Li X, Fu B, Feng P, Wu B, Shu HB, Zhang J*. (2023) STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nature Cell Biology 25: 1208–1222.

3. Tian X, Zhou Y, Wang S, Gao M, Xia Y, Li Y, Zhong Y, Xu W, Bai L, Fu B, Zhou Y, Lee HR, Deng H, Lan K, Feng P, Zhang J*. (2023) Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses. mBio 14: e0054923.

4. Xie J, Wang S, Zhong Y, Gao M, Tian X, Zhang L, Pan D, Qin Q, Wu B, Lan K, Sun ZJ*, Zhang J*. (2023) Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. Molecular Therapy-Oncolytics 29: 61-76.

5. Su W, Qiu W, Li SJ, Wang S, Xie J, Yang QC, Xu J, Zhang J*, Xu Z*, Sun ZJ*. (2022) A Dual-Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis. Advanced Materials 35: e2209379.

6. Sun X, Liu T, Zhao J, Xia, H, Xie J, Guo Y, Zhong L, Li M, Yang Q, Peng C, Rouvet I, Belot A, Shu HB, Feng P*, Zhang J* (2020). DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. Nature communications 11 (1): 6182.

7. Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo GJ, Chen L, Stabell AC, Xia Z, Sawyer SL, Jung JU, Huang C, Feng P (2018). Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication. Cell Host&Microbe 24(2): 234-248. (Highlighted by Science Signaling http://stke.sciencemag.org/content/11/547/eaav3302)

8. Zhang J, Feng H, Zhao J, Feldman ER, Chen S, Yuan W, Huang C, Akbari O, Tibbetts SA, and Feng P (2016). IkappaB Kinase epsilon Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Reports 16: 405-418.

9. Zhang J*, Feng H, Xu S, Feng P (2016). Hijacking GPCRs by viral pathogens and tumor. Biochem Pharmacol 114: 69-81. (Review)

10. Zhang J*, Tian M, Xia Z, Feng P (2016). Roles of IκB kinase ε in the innate immune defense and beyond. Virologica Sinica 31(6): 457-465. (Review)

11. Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao S, Tibbetts SA, and Feng P (2015). Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS Pathogens 11: e1005001.

12. Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, and Feng P (2015). Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. PLoS Pathogens 11: e1004768.

13. Minassian A^#, Zhang J^#, He S, Zhao J, Zandi E, Saito T, Liang C, and Feng P (2015). An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathogens 11: e1005060.

14. Zhang J, Liu T, Tong X, Li G, Yan J, Ye X. Identification of novel virus inhibitors by influenza A virus specific reporter cell-based screening (2011). Antiviral Research 93:48-54.

15. Zhang J, Li G, Ye X. Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II (2010). Journal of Virology 84:12619-27.

16. Zhang J, Li G, Liu X, Wang Z, Liu W, Ye X. Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA (2009). Journal of General Virology 90:2751-8.