Research
Mechanism of glycans-involved infection and immunity evasion of human important intracellular pathogens such as Mycobacterium tuberculosis and Hepatitis Virus
Representative Publications
Pan Q; Xie Y; Zhang Y; Guo X; Wang J; Liu M*; Zhang X-L* (2024) EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses, Nature Communications, 15(1): 652
Yao Q; Xie Y; Xu D; Qu ZL; Wu J; Zhou YY; Wei YY; Xiong H; Zhang X-L* (2022) Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3, Cellular & Molecular Immunology, 19(8): 883-897
Qu Z; Zhou J; Zhou Y; Xie Y; Jiang Y; Wu J; Luo Z; Yin Le*; Zhang X-L* (2020) Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway., Science Advances, 6(43): eaba4733
Bian WX#, Xie Y#, Wang XN, Xu GH, Fu BS, Li S, Long G, Zhou X*, Zhang X-L* (2019) Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication. Nucleic Acids Res, 47(1):56-68.
Sun X; Pan Q; Yuan C; Wang Q; Tang XL; Ding K; Zhou X; Zhang X-L** (2016) A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guerin Enhances Immunoprotective Effect against Tuberculosis, Journal of the American Chemical Society, 138(36): 11680-11689
Wang SR#, Min YQ#, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T*, Zhang XL*, Zhou X* (2016) A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2(4): e1501535.
