Education

• 2001.09-2005.07 Shanghai Jiao Tong University, Biotechnology, Bachelor's Degree

• 2005.09-2011.07 Peking University, Biotechnology, Doctoral Degree

Academic Experience

• 2011.09-2015.03 Postdoctoral Researcher, BIOPIC, Peking University

• 2012.03-2012.09 Visiting Scholar, Department of Chemistry and Chemical Biology, Harvard University, USA

• 2015.04-2018.12 Assistant Researcher, BIOPIC, Peking University

• 2019.02-Present Professor, Institute of Medical Research/Frontier Science Center for Immunology and Metabolism, Wuhan University

• 2019.08-Present Adjunct Professor, School of Stomatology, Wuhan University

Awards & Honors

National High-Level Talent Special Support Programs (2021)

Distinguished Professor under the Chu Tian Scholars Program of Hubei Province (2021)

Excellent Youth Foundation of Hubei Scientific Committee (2021)

Representative Publications

1. Zhou, Y., Liao, H., Pei, L., and Pu, Y* (2023). Combatting persister cells: The daunting task in post-antibiotics era. Cell Insight 2, 100104. 10.1016/j.cellin.2023.100104.

2. Zhang P^#, Qiu Y^#, Wang Y^#, Xiao Y, Yu S, Shi M, Ni Y, Miron R J, Pu Y*, Zhang Y*  (2022) Nanoparticles Promote Bacterial Antibiotic Tolerance via Inducing Hyperosmotic Stress Response，Small, https://doi.org/10.1002/smll.202105525

3. Qiu Y^#, Yu S^#, Wang Y^#, Xiao L, Pei L, Pu Y*, Zhang Y*. (2022) Photothermal Therapy may be a Double-edge Sword by Inducing the Formation of Bacterial Antibiotic Tolerance. Biomaterials Science, 00，1-11.

4. Liu Z^#, Wang A^#, Pu Y^#, Li Z, Xue D, Zhang C, Xiang X, E J, Bu Z, Bai F & Ji J. (2021) Genomic and Transcriptomic Profiling of Hepatoid Adenocarcinoma of the Stomach. Oncogene, 40, 5705–5717.

5. Tong, Y.^{*, #} , Zhang, J.^#, Sun, N. ^#, Wang, X. ^#, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).

6. Mancini L, Terradot G, Tian T, Pu Y, Li Y, Lo C, Bai F and Pilizota T. (2020) A General Workflow for Characterization of Nernstian Dyes and Their Effects on Bacterial Physiology. Biophysical Journal, 117, 4–14.

7. Pu Y, Li Y, Bai F, et al. (2019). ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance. Molecular Cell, 73(1):143-156.

8. Pu Y, Ke Y, Bai F. (2017). Active efflux in dormant bacterial cells - New insights into antibiotic persistence. Drug Resist Updat 30, 7-14.

9. Jin L, Qin Q, Wang Y, Pu Y, Li Y, et al. (2017). Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development. PLoS Pathogens 12(9):e1005847.

10. Pu Y, Zhao Z, Li Y, Bai F, Xie X, et al. (2016). Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells. Molecular Cell, 62, 284-294. (Highlighted by Nature https://www.nature.com/articles/nature18442 and Nature Review Microbiology https://www.nature.com/articles/nrmicro.2016.72)

11. Guo X, Jin X, Lv X, Pu Y, Bai F*. (2015) Real Time Visualization of Perylene Nano-clusters (PNCs) in Water and Their Partitioning to Graphene Surface and Macrophage Cells. Environmental Science & Technology, 49 (13): 7926-7933.

12. Liu Y, Yang J, Zhao Z, Pu Y*, Bai F*. (2014) Bacterial Persistence. Science China Chemistry, 57 (12): 1625-1633

13. Pu Y, Kikuchi A, Moriyasu Y, Tomara M, Jin Y, Suga H, Wei T, Li Y, Omura T. (2011) Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects -implications for the virus origin. Journal of Virology, 85 (6): 2975-2979.

14. Akita F, Higashiura A, Shimizi T, Pu Y, Suzuki M, Ichiki T, Sasaya T, Kanamaru S, Arisaka F, Tsukihara T, Nakagawa A, Omura T. (2012) Crystal Structure and Octamerization of the Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus. Journal of Virology, 86 (2): 746-756.

15. Zhou F, Pu Y, Wei T, Liu H, Deng W, Wei CH, Ding B, Omura T, Li Y. (2007). The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusionin insect host cells. Proceedings of the National Academy of Sciences USA. 104(49): 19547-19552.

16. Zhou F, Wu G, Deng W, Pu Y, Wei C, Li Y. (2007). Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8. Febs Letters 581(1): 34-40.