Ion channels serve as the functional interface between the body and the surrounding environment, acting as an indispensable signaling pathway for the organism to communicate with the internal and external environment. Upon detecting internal or external stimuli, ion channels are capable of converting these stimuli into electric signals, which are then propagated to the brain or other parts of the nervous system. The nervous system then responds to these stimuli. The group's primary focus is on transient receptor potential vanilloid (TRPV) channels that are involved in temperature sensation and nociception. These channels are distributed widely in both neural and non-neural tissues and play an essential role in core physiological processes, such as somatosensory information transduction and central information processing. One of his research aspects is trying to elucidate the biophysical and structural basis for the sensation of environmental stimuli by these TRPV channel proteins. This will facilitate the elucidation of the mechanisms underlying the gating and regulation of TRPV channels in physiological and pathological conditions. The other endeavor of his group is attempting to explore the functional roles of several ion channels in immune cells and their activities in antiviral immune responses.
Yu-Yao Guo#, Yue Gao#, Yun-Lin Zhao#, Chang Xie#, Hu Gan, Xufeng Cheng, Li-Ping Yang, Junyan Hu, Hong-Bing Shu, Bo Zhong*, Dandan Lin*, Jing Yao*. Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. Cell Rep., 2024 Apr 12; 43(4):114095.
Quan Tian#, Peiyu Wang#, Chang Xie#, Peiyuan Pang, Youjing Zhang, Yue Gao, Zhijian Cao, Yingliang Wu, Wenxin Li, Michael X. Zhu, Dongdong Li, Jing Yao*. Identification of an arthropod molecular target for plant-derived natural repellents. Proc. Natl. Aca. Sci. USA. 2022, May 3;119(18): e2118152119.
Yu-Yao Guo#, Yue Gao#, Yu-Ru Hu, Yuhan Zhao, Dexiang Jiang, Yulin Wang, Youjing Zhang, Hu Gan, Chang Xie, Zheng Liu, Bo Zhong, Zhi-Dong Zhang*, Jing Yao*. The transient receptor potential vanilloid 2 (TRPV2) channel facilitates virus infection through the Ca2+-LRMDA axis in myeloid cells. Adv Sci (Weinh). 2022 Dec; 9(34): e2202857.
Xiaoyi Mo#, Peiyuan Pang#, Yulin Wang, Dexiang Jiang, Mengyu Zhang, Yang Li, Peiyu Wang, Qizhi Geng, Chang Xie, Hai-Ning Du, Bo Zhong, Dongdong Li, Jing Yao*. Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel. eLife. 2022 Jun 10; 11: e78301.
Quan Tian#, Juan Hu#, Chang Xie#, Kaidi Mei, Cuong Pham, Xiaoyi Mo, Régine Hepp, Sylvia Soares, Fatiha Nothias, Yuanyuan Wang, Qiang Liu, Fen Cai, Bo Zhong, Dongdong Li*, Jing Yao*. Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane. Proc. Natl. Aca. Sci. USA. 2019 Mar 12; 116(11):5170-5175.
Qiang Liu#, Jin Wang#, Xin Wei, Juan Hu, Conghui Ping, Yue Gao, Chang Xie, Peiyu Wang, Peng Cao, Zhengyu Cao, Ye Yu, Dongdong Li, Jing Yao*. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine. eLife. 2021 Apr 20; 10: e68128.
