Education

2005.9 - 2010.7: Ph.D. in Cell Biology, Peking University

2001.9 - 2005.7: B.S. in Biological Science, Peking University (Minor in Computer Software)

Academic Experience

2015.7 - present: Principal Investigator & Professor, Medical Research Institute, Wuhan University

2012.7 - 2015.6: Research Fellow, Harvard Medical School / Boston Children’s Hospital

2011.2 - 2012.6: Postdoctoral Research Associate, University of North Carolina at Chapel Hill

Awards & Honors

HMS Epigenetics Initiative Travel Grant (2015)

Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013)

Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015)

Excellent Graduate, Peking University (2010)

Social Service

Associate Editor for Frontiers in Cell and Developmental Biology, Frontiers in Genetics (2020-2023)

Editorial Board member, Science Bulletin (2018-202)

Reviewer for: Nat Commun, Cell Reports, Cell Genomics, Advanced Science, National Science Review, Mol Psychiatry, Acta Biomaterialia, Semin Cell Dev Biol, Bioactive Materials, Science Bulletin, SCIENCE CHINA Life Sciences, iScience, Stem Cells, FASEB J, Cell Mol Life Sci, Materials Today Bio, Tissue Engineering, Stem Cells Translational Medicine, Stem Cell Research & Therapy, Cell Proliferation, STAR Protocols, Genes & Diseases, Neural Regen Res, Int J Mol Sci, Cell Insight, Front Genet, Cells, et al.

Representative Publications (33/60; total citations >4000 by Google Scholar: http://scholar.google.com/citations?user=ak1phyQAAAAJ&hl=en)

1. Lai Jiang, Chenchao Yan, Ying Yi, Lihang Zhu, Zheng Liu, Donghui Zhang*, Wei Jiang*. Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling. Stem Cell Reports 2024. DOI: 10.1016/j.stemcr.2024.07.001.

2. Liwen Jiang, Linfeng Huang*, Wei Jiang*. H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation. Cell Insight 2024. 3(4):100180. DOI: 10.1016/j.cellin.2024.100180.

3. Ying Yi, Xianchun Lan, Yinglei Li, Chenchao Yan, Jing Lv, Tianzhe Zhang, Wei Jiang*. Fatty acid synthesis and oxidation regulate human endoderm differentiation by mediating SMAD3 nuclear localization via acetylation. Developmental Cell 2023. 58(18):1670-1687. DOI: 10.1016/j.devcel.2023.07.005.

4. Pei Lu#, Jie Yang#, Mao Li#, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang*. A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome Biology 2023. 24(1):92. DOI: 10.1186/s13059-023-02925-w.

5. Chenchao Yan, Yajing Meng, Jie Yang, Jian Chen*, Wei Jiang*. Translational landscape in human early neural fate determination. Development 2023. 150 (6): dev201177. DOI: 10.1242/dev.201177.

6. Li Li#, Zhongjun Wan#, Ruxiang Wang, Yuxin Zhao, Yida Ye, Pengcheng Yang, Yan Qi, Wei Jiang*, Lin Cai*, Donghui Zhang*. Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells. Cell Discovery 2022. 8:105. DOI: 10.1038/s41421-022-00446-7.

7. Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang*. PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression. Nature Communications 2022. 13(1):4601. DOI: 10.1038/s41467-022-32295-z.

8. Tianzhe Zhang, Ran Zheng, Mao Li, Chenchao Yan, Xianchun Lan, Bei Tong, Pei Lu, Wei Jiang*. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Research 2022. 50(9): 4959-4973. DOI: 10.1093/nar/gkac265.

9. Fang Xie#, Lai Jiang#, Ximian Xiao#, Yiwen Lu, Runhui Liu*, Wei Jiang*, Jie Cai*. Quaternized polysaccharide-based cationic micelles as a macromolecular approach to eradicate multidrug-resistant bacterial infections while mitigating antimicrobial resistance. Small 2022. 18(12):e2104885. DOI: 10.1002/smll.202104885.

10. Jing Lv#, Ying Yi#, Yan Qi, Chenchao Yan, Wenwen Jin, Liming Meng, Donghui Zhang*, Wei Jiang*. Mitochondrial homeostasis regulates definitive endoderm differentiation of human pluripotent stem cells. Cell Death & Discovery 2022. 8:69. DOI: 10.1038/s41420-022-00867-z.

11. Yan Qi#, Yida Ye#, Ruxiang Wang, Senlin Yu, Yue Zhang, Jing Lv, Wenwen Jin, Shutao Xia, Wei Jiang*, Yifei Li*, Donghui Zhang*. Mitochondrial dysfunction by TFAM depletion disrupts self-renewal and lineage differentiation of human PSCs by affecting cell proliferation and YAP response. Redox Biology 2022. 50:102248. DOI: 10.1016/j.redox.2022.102248.

12. Wenwen Jin, Wei Jiang*. Stepwise differentiation of human pluripotent stem cells into functional pancreatic β cells. Cell Regeneration 2022. 11(1):24. DOI: 10.1186/s13619-022-00125-8.

13. Lai Jiang, Yiru Shen, Yajing Liu, Lei Zhang*, Wei Jiang*. Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies. Theranostics 2022. 12(4):1537-1556. DOI: 10.7150/thno.66670.

14. Song Ding#, Xianchun Lan#, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li*, Jian Chen*, Wei Jiang*. CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis. Cell Death & Disease 2021. 12(11):981. DOI: 10.1038/s41419-021-04292-5.

15. Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Yingan Jiang*, Wei Jiang*. Depletion of demethylase KDM6 enhances early neuroectoderm commitment of human PSCs. Frontiers in Cell and Developmental Biology 2021. 9:702462. DOI: 10.3389/fcell.2021.702462.

16. Ran Zheng#, Ting Geng#, Dan-Ya Wu#, Tianzhe Zhang, Hainan He, Hai-Ning Du, Donghui Zhang*, Yi-Liang Miao*, Wei Jiang*. Derivation of feeder-free human extended pluripotent stem cells. Stem Cell Reports 2021. 16(7):1686-1696. DOI: 10.1016/j.stemcr.2021.06.001.

17. Ran Liu#, Kaiyu Qian#, Yu Xiao*, Wei Jiang*. Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research 2021. 53:102299. DOI: 10.1016/j.scr.2021.102299.

18. Pei Lu#, Mao Li#, Donghui Zhang*, Wei Jiang*. Lnc-ing pluripotency maintenance and early differentiation in human pluripotent stem cells. FASEB Journal 2021. 35(4): e21438. DOI: 10.1096/fj.202002278R.

19. Jie Yang#, Pei Lu#, Mao Li, Chenchao Yan, Tianzhe Zhang, Wei Jiang*. GATA6-AS1 regulates GATA6 expression to modulate human endoderm differentiation. Stem Cell Reports 2020. 15(3):694-705. DOI: 10.1016/j.stemcr.2020.07.014.

20. Jie Yang, Wei Jiang*. The roles of SMAD2/3 in human embryonic stem cells. Frontiers in Cell and Developmental Biology 2020. 8:653. DOI: 10.3389/fcell.2020.00653.

21. Yangyang Yu, Wei Jiang*. Pluripotent stem cell differentiation as an emerging model to study human prostate development. Stem Cell Research & Therapy 2020. 11(1):285. DOI: 10.1186/s13287-020-01801-9.

22. Mengtian Tan, Lai Jiang, Yinglei Li, Wei Jiang*. Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells. Stem Cells International 2019. 2019(5026793):1-15. DOI: 10.1155/2019/5026793.

23. Xiaojuan Su#, Mengtian Tan#, Bo Duan, Jie Cai*, Wei Jiang*, Lina Zhang*. Hierarchical microspheres with macropores fabricated from chitin as 3D cell culture. Journal of Materials Chemistry B 2019. 7(34), 5190-5198. DOI: 10.1039/c9tb01046g.

24. Ting Geng, Donghui Zhang, Wei Jiang*. Epigenetic regulation of transition among different pluripotent states. Stem Cells 2019. 37(11):1372-1380. DOI: 10.1002/stem.3064.

25. Yinglei Li, Wei Jiang*. The path and surface marker of SC-β cells. Science Bulletin 2019. 64(16): 1122-1124. DOI: 10.1016/j.scib.2019.06.018.

26. Donghui Zhang*, Wei Jiang*. From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 2015. 65 (5): 468-475. DOI: 10.1093/biosci/biv016.

27. Wei Jiang*, Yuting Liu, Rui Liu, Kun Zhang, Yi Zhang*. LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 2015. 11(1), 137-148. DOI: 10.1016/j.celrep.2015.03.008.

28. Wei Jiang*, Donghui Zhang, Nenad Bursac, Yi Zhang*. WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 2013. 1 (1), 46-52. DOI: 10.1016/j.stemcr.2013.03.003.

29. Wei Jiang, Jinzhao Wang, Yi Zhang*. Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 2013. 23(1), 122-130. DOI: 10.1038/cr.2012.119.

30. Wei Jiang#, Xin Sui#, Donghui Zhang, Meng Liu, Mingxiao Ding, Yan Shi*, Hongkui Deng*. CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 2011. 29(4):609-617. DOI: 10.1002/stem.608.

31. Donghui Zhang#, Wei Jiang#, Meng Liu, Xin Sui, Xiaolei Yin, Song Chen, Yan Shi, Hongkui Deng*. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 2009. 19(4):429-438. DOI: 10.1038/cr.2009.28.

32. Wei Jiang#, Zhaodai Bai#, Donghui Zhang, Yan Shi, Jun Yong, Song Chen, Mingxiao Ding, Hongkui Deng*. Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 2008. 51:1671-1679. DOI: 10.1007/s00125-008-1065-1.

33. Wei Jiang#, Yan Shi#, Dongxin Zhao, Song Chen, Jun Yong, Jing Zhang, Tingting Qing, Xiaoning Sun, Peng Zhang, Mingxiao Ding, Dongsheng Li*, Hongkui Deng*. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 2007. 17:333-344. DOI: 10.1038/cr.2007.28.