Research

Regulatory mechanisms of tumor metabolism and microenvironment

Representative Publications

1. Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik E, Fan C, Li Y* (2020). Dynamic regulation of ME1 phosphorylation and acetylation affects lipid metabolism and colorectal tumorigenesis. Molecular Cell, 77:138-149.

2. Chen Z, Zhou X, Zhou X, Tang Y, Lu M, Zhao J, Tian C, Wu M, Liu Y, Prochownik E, Wang F, Li Y* (2023). Phosphomevalonate Kinase Controls β-Catenin Signaling via the Metabolite 5-Diphosphomevalonate. Advanced Science, 10:e2204909.

3. Gu L, Zhu Y, Lin X, Lu B, Zhou X, Zhou F, Zhao Q, Prochownik E, Li Y* (2021). The IKKβ-USP30-ACLY axis controls lipogenesis and tumorigenesis. Hepatology, 73:160-174.

4. Zhu Y, Gu L, Lin X, Zhou X, Lu B, Li C, Li Y, Prochownik E, Karin M, Wang F, Li Y*(2023). P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology, 77:1499-1511.

5. Li Y, Cui K, Zhang Q, Li X, Lin X, Tang Y, Li Y* (2021). FBXL6 degrades phosphorylated p53 to promote tumor growth. Cell Death & Differentiation, 28:2112-2125.

6. Cui K, Liu C, Li X, Zhang Q, Li Y* (2020). Comprehensive characterization of the rRNA metabolism-related genes in human cancer. Oncogene, 39:786-800.

7. Gu L, Zhu Y, Lin X, Li Y, Cui K, Li Y* (2018). Amplification of glyceronephosphate O-acyltransferase and recruitment of USP30 stabilize DRP1 to promote hepatocarcinogenesis. Cancer Research, 78:5808-5819.

8. Han H, Sun D, Li W, Shen H, Zhu Y, Li C, Chen Y, Lu L, Li W, Zhang J, Tian Y and Li Y* (2013). A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis. Hepatology, 6:2378–2389.