Research

Cholesterol metabolism and genetic causes of cholesterol-related diseases

Representative Publications

1. Zhou YX, Wei J, Deng G, Hu A, Sun PY, Zhao X, Song BL*, Luo J* (2023). Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesis. Nature Cell Biology 25:937-949.

2. Wang JK, Li Y, Zhao X, Liu YB, Tan J, Xing YY, Adi D, Wang YT, Fu ZY, Ma YT, Liu SM, Liu Y, Wang Y, Shi XJ, Lu XY, Song BL*, Luo J* (2022). Ablation of plasma prekallikrein decreases LDL cholesterol by stabilizing LDL receptor and protects against atherosclerosis. Circulation 145:675-687.

3. Meng FH, Liu S, Xiao J, Zhou YX, Dong LW, Li YF, Zhang YQ, Li WH, Wang JQ, Wang Y, Song BL, Ma YT*, Fu ZY*, Luo J* (2023). New loss-of-function mutations in PCSK9 reduce plasma LDL cholesterol. Arteriosclerosis, Thrombosis, and Vascular Biology 43:1219-1233.

4. Fang XX, Wei P, Zhao K, Sheng ZC, Song BL*, Yin L*, Luo J* (2024). Fatty acid-binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes. Journal of Cell Biology 223:e202211062.

5. Luo J, Yang H, Song BL* (2020). Mechanisms and regulation of cholesterol homeostasis. Nature Reviews Molecular Cell Biology 21:225-245.