Research

The molecular mechanisms linking cellular stress pathways, metabolic dysfunctions and aging-associated inflammatory diseases

Representative Publications

1. Chen Y, Wu Z, Huang S, Wang X, He S, Liu L, Hu Y, Chen L, Chen P, Liu S, He SQ, Shan B, Zheng L, Duan S, Song Z, Jiang L, Wang QA, Gan Z, Song BL, Liu J, Rui LY, Shao M, Liu Y* (2022) . Adipocyte IRE1ɑ promotes PGC1ɑ mRNA decay and restrains adaptive thermogenesis. Nat Metab. 4(9):1166-1184.

2. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*, Liu Y* (2021). IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 131(17):e143737.

3. Wu Y, Shan B, Dai J, Xia Z, Cai J, Chen T, Lv S, Feng Y, Zheng L, Wang Y, Liu J, Fang J, Xie D, Rui L, Liu J, Liu Y* (2018). Dual Role for Inositol-requiring Enzyme 1α in Promoting the Development of Hepatocellular Carcinoma during Diet-induced Obesity. Hepatology 68:533-546.

4. Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*, Liu Y* (2017). The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages to Impair Energy Expenditure in Obesity. Nat Immunol. 18:519-529.

5. Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y* (2015). Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses. J Hepatol. 62:590-598.