Research
Mechanisms of bacteria-host interactions
Mechanisms of bacterial infection and pathogenesis
Representative Publications (#: contributed equally)
Lian H#, Park D#, Chen M, Schueder F, Lara-Tejero M, Liu J, Galán JE* (2023). Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. Nature Microbiology 10:1880-1895.
Lian H#, Jiang K#, Tong M#, Chen Z, Liu X, Galán JE*, Gao X* (2021). The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response. Nature Microbiology 5:658-671.
Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB* (2018). The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity 3:438-448.e5.
Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S, Shu HB* (2018). ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nature Communications 1:3349.
Wei J#, Lian H#, Guo W, Chen YD, Zhang XN, Zang R, Zhong L, Yang Q, Hu MM, Luo WW, Shu HB*, Li S* (2018). SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA. PLoS Pathogens 10:e1007336.
