科学研究
The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network
2023-04-04The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma
2023-03-29Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas
2023-03-16Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity
2023-03-16RNA helicase DHX15 exemplifies a unique dependency in acute leukemia
2023-03-02β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response
2023-02-01Dual-Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
2022-12-22Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
2022-12-17Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response
2022-10-25The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS
2022-10-13DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9
2022-10-1020220913 CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression
2022-09-1420220819 The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation
2022-09-1320220817 Renal NF-kappaB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting
2022-09-1220220806 PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression
2022-09-12
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