学习经历

1983-1987 兰州大学生物学系动物学专业，学士

1987-1990 中国医学科学院基础医学研究所细胞生物学研究室，硕士

1992-1995 美国Emory大学细胞及发育生物学专业，博士

1995-1997 美国Tularik公司David Goeddel实验室，博士后

工作经历与任职

1990-1992 美国密西根大学医学中心，研究助理

1997-1998 美国Magainin制药公司，资深科学家

1998-2003 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，助理教授

2003-2005 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，副教授

2000-2004 北京大学生命科学学院，长江特聘教授

2005-2013 武汉大学生命科学学院，教授、院长

2013-2022 武汉大学副校长

2014- 武汉大学医学研究院院长

2019- 教育部免疫与代谢前沿科学中心首席科学家

2019- 中国医学科学院天然免疫与炎性疾病创新单元主任

2022- 武汉生物技术研究院院长

研究方向

抗病毒天然免疫、炎症、炎癌转化、肿瘤免疫治疗

获奖与荣誉

中国科学院院士（2011）

发展中国家科学院院士（2012）

《自然》杰出导师奖（2015）

国家自然科学二等奖两项（第一完成人，2010，2015）

教育部自然科学奖一等奖两项(第一完成人，2006，2014)

湖北省科学技术突出贡献奖（2022）

第十三届全国政协常委（2018-2023）

第十四届全国政协常委（2023-）

Cell Insight主编（2021-）

代表性论文（46 of 197）

1. Hsu H, Shu HB, Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell 84:299-308.

2. Shu HB, Takeuchi M, Goeddel DV* (1996). The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. PNAS 93:13973-13978.

3. Shu HB, Halpins DR, Goeddel DV* (1997). Casper is a FADD and Caspase-related Inducer of Apoptosis. Immunity 6:751-763.

4. Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV and M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis. Science 279:1954-1958.

5. Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J Leukocyte Biol 65:680-683.

6. Shu HB*, Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1. PNAS 97:9156-9161.

7. Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394.

8. Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, and Zhang G* (2003). Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423:49-56.

9. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* (2005). VISA is an adapter protein required for virus-triggered signaling. Molecular Cell 19:727-740.

10. Huang J, Liu T, Chen D, Zhai Z, Shu HB* (2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J 24:4018-4028.

11. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB* (2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. PNAS 104:11706-11711.

12. Zhang BC, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB* (2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Research 18:900-910.

13. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Immunity 29:538-550.

14. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB* (2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA. Immunity 30:397-407.

15. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB* (2009). ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. PNAS 106:7945-7950.

16. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu HB* (2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. PNAS 107:815-820.

17. Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB* (2010). The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Research 20:802-811.

18. Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB* (2010). GSK3b regulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation. Immunity 33:878-889.

19. Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB*, Wang YY* (2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination. PNAS 108:19341-19346.

20. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB* (2012). LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PNAS 109:11770-11775.

21. Wang YY, Ran Y, Shu HB* (2012).Linear ubiquitination of NEMO brakes the antiviral response.Cell Host Microbe 12:129-131.

22. Chen R, Li M, Zhang Y, Zhou Q, Shu HB* (2012). The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. PNAS 109:14128-14133.

23. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB* (2014). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. PNAS 114:1509-1514.

24. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B, Shu HB*, Wang YY* (2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 16:450-461.

25. Shu HB*, Wang YY*(2014). Adding to the STING. Immunity 41:871-873.

26. Luo WW, Li S, Li C , Lian H, Yang Q, Zhong, B, Shu, HB*(2016).iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol 17: 1057-1066.

27. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB* (2016). Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity 45: 555-569.

28. Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB*(2017). Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 21:231-243.

29. Hu MM, Liao CY, Yang Q, Xie XQ, Shu HB*(2017). Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med 214:973-989.

30. Wei J, Guo W, Lian H, Yang Q, Lin H, Li S*, Shu HB*(2017). SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. PNAS 114:13000-13005.

31. Hu MM, Shu HB*(2018). Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids. Annu Rev Cell Dev Biol 34:357-379.

32. Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S*, Shu HB*(2018). ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nat Commun. 9: 3349. doi: 10.1038/s41467-018-05559-w

33. Zhang HX, Xu ZS, Lin H, Li M, Xia T, Cui KS, Wang SY, Li YJ, Shu HB*, Wang YY*(2018). TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis. Nat Commun. 9: 3441. doi: 10.1038/s41467-018-05796-z

34. Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S*, Shu HB*(2018). The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity 49: 438-448.

35. Lin H, Gao D, Hu MM, Zhang M, Wu XX, Feng L, Xu WH, Yang Q, Zhong X, Wei J, Xu ZS, Zhang HX, Song ZM, Zhou Q, Ye W, Liu Y, Li S, Shu HB*(2018). MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. PNAS 115: 12483-12488.

36. Hu MM*, He WR, Gao P, Yang Q, He K, Cao LB, Li S, Feng YQ, Shu HB* (2019). Virus-induced accumulation of intracellular bile acids activates the TGR5-beta-arrestin-SRC axis to enable innate antiviral immunity. Cell Research 29(3):193-205.

37. Wu X, Lei CQ, Xia T, Zhong X, Yang Q, Shu HB* (2019). Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nat Commun 10:4115.

38. Xia T, Yi XM, Wu X, Shang J, Shu HB*(2019). PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response. PNAS 116:20063-20069.

39. Hu MM, Shu HB*(2020). Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases. Ann Rev Immunol 38:78-89.

40. Song ZM, Lin H, Yi XM, Guo W, Ming-Ming Hu, Shu HB*(2020). KAT5 acetylates cGAS to promote innate immune response to DNA virus. PNAS 117:21568-21575.

41. He WR, Cao LB, Yang YL, Hua D, Hu MM, Shu HB*(2021). VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release. Cell Mol Immunol 18(5):1186-1196.

42. Li C, Feng L, Luo WW, Lei CQ, Li M, Shu HB* (2021). The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response. Cell Discovery 7 (1):46.

43. Su S#, Hua D#, Li JP#, Zhang XN, Bai L, Cao LB, Guo Y, Zhang M, Dong JZ, Liang XW, Lan K, Hu MM*, Shu HB* (2022). Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone. Signal Transduction and Targeted Therapy 7(1):137.

44. Zhong B, Shu HB* (2022). MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism, and intervention. Curr Opin Immunol 78:102248.

45. Guo Y, Zhang XN, Su S, Ruan ZL, Hu MM*, Shu HB* (2023). β-adrenoreceptor-triggered PKA activation negatively regulates the innate antiviral response. Cell Mol Immunol 20(2):175-188.

46. Hu MM, Shu HB* (2023). Mitochondrial DNA-triggered innate immune response: mechanisms and diseases. Cell Mol Immunol 20 (12): 1403-1412.