Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to govern anti-tumor immunity

A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA

A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression

Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance

Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia

Rapid generation of long, chemically modified pegRNAs for prime editing

Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale