学习经历

1999-2003 南京大学生命科学学院，学士

2004-2010 美国科罗拉多大学医学中心，博士，导师：Cynthia Ju

工作经历与任职

2010-2016 美国麻省理工学院，博士后，导师：Robert Langer和Daniel Anderson

2016-2018 美国福泰制药，研究员

2018-至今 武汉大学医学研究院，教授

研究方向

基因编辑/核酸疗法

人才项目和资助

2024 国家杰出青年科学基金

2019 国家重点研发计划，课题组长

2018 国家高层次人才青年项目A类资助

2009 国家优秀自费留学生奖学金

研究内容简介

聚焦新型RNA疗法、基因编辑的工具开发和其临床转化，采用包括分子遗传学、材料化学、核酸化学、生物信息学等多学科知识和研究手段，研发新型基因组编辑工具和递送技术，发展CRISPR 对疾病进行高效诊断技术，证明CRISPR 治疗遗传病的可行性，为CRISPR 的临床转化奠定基础。已在国际刊物发表和接收论文50余篇，被引用12000余次，10篇论文入选ESI高被引论文，多项研究成果被国际主流媒体报道和Nature系列杂志专文评述。

实验室研究生获奖

武汉大学“研究生学术创新奖”特等奖 1人次

国家奖学金 1人次

阳普医疗奖学金 1人次

瑞科奖学金 1人次

光谷奖学金 2人次

义翘神州奖学金 2人次

宜昌人福奖学金 5人次

学业奖学金 8人次

代表性论文

入职武汉大学后发表的代表性论文

1. Lei X#, Huang A#, Chen D#, Wang X#, Ji R, Wang J, Zhang YZ, Zhang YM, Lu S, Zhang K, Chen Q, Zhang Y, Yin H*. Nature Biotechnology, 2024. In Press

2. Zhang R^#, He Z^#, Shi Y^#, Sun X^#, Chen X^#, Wang G, Zhang Y, Gao P, Wu Y, Lu S, Duan J, Sun S, Yang N, Fan W, Zhao K, Yang B, Xia Y, Zhang Y, Zhang Y, Yin H*. Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale. Cell, 2024 Jun 19:S0092-8674(24)00637-8.

3. Chen Q, Wang X, Zhang Y, Tian M, Duan J, Zhang Y, Yin H*. Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing. National Science Review, 2024 Apr 3;11(6): PMC11104531.

4. Tong X^#, Zhang K^#, Han Y^#, Li T, Duan M, Ji R, Wang X, Zhou X, Zhang Y, Yin H*, Fast and Sensitive CRISPR Detection by Minimized Interference of Target Amplification Nature Chemical Biology, 2024 Jul;20(7):885-893.

5. An J^#, Zhang CP^#, Qiu HY^#, Zhang HX^#, Chen QB, Zhang YM, Lei XL, Zhang CX, Yin H*, Zhang Y*. Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway. Nature Biomedical Engineering, 2023

6. Wang J^#, He Z^#, Wang G^#, Zhang R^#, Duan J, Gao P, Lei X, Qiu H, Zhang C, Zhang Y, Yin H*, Efficient targeted insertion of large DNA fragments without DNA donor, Nature Methods, 2022 Mar;19(3):331-340.

7. Lu S^#, Tong X^#, Han Y^#, Zhang K, Zhang Y, Chen Q, Duan J, Lei X, Huang M, Qiu Y, Zhang DY, Zhou X, Zhang Y*, Yin H*, Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a, Nature Biomedical Engineering, 2022 Mar;6(3):286-297

Nature Biomedical Engineering编辑部评述 “Rethinking diagnostics for pandemic readiness”

8. Wang L^#, Xue W^#, Zhang H^#, Gao R^#, Qiu H^#, Wei J, Zhou L, Lei YN, Wu X, Li X, Liu C, Wu J, Chen Q, Ma H, Huang X, Cai C, Zhang Y, Yang B*, Yin H*, Yang L*, Chen J*, Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nature Cell Biology. 2021 May;23(5):552-563.

9. Song CQ^#, Jiang T^#, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR*, Yin H*, Xue W*, Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. 2020 Jan;4(1):125-130.

专文评述: Nature Biomedical Engineering “Correcting tyrosinaemia via a point mutation”

Nature Biomedical Engineering “Towards better base editing”

F1000 推荐

10. Lu S^#, Li F^#, Chen Q, Wu J, Duan J, Lei X, Zhang Y, Zhao D, Bu Z*, Yin H*, Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics, Cell Discovery, 2020, 6:18

11. Yin H*, Xue W*, Anderson DG* CRISPR-Cas: a tool for cancer research and therapeutics. Nature Reviews Clinical Oncology. 2019 May;16(5):281-295.

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文选集

12. Chen Q, Zhang Y*, Yin H*, Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing. Advanced Drug Delivery Reviews 2021 Jan;168:246-258

13. Wu J, Yin H*. Engineering guide RNA to reduce the off-target effects of CRISPR. Journal of Genetics and Genomics. 2019 Nov 20;46(11):523-529.

14. Zhang HX, Zhang Y*, Yin H*. Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9. Molecular Therapy. 2019 Apr 10;27(4):735-746

入职武汉大学前发表的代表性论文

15. Yin H^#, Song CQ#, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ,Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG，Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nature Chemical Biology.2018, 14(3):311-316.

专文评述: Nature Catalysis “Better guidance is cheaper”

BioCentury | Altering Cas9 and its guide for fewer off-target edits.

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文集

16. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nature Biotechnology 2017, 35(12):1179-1187.

*媒体报道：Featured by VOICE of America / US Researchers Use Nanotech, Gene Editing to Edit Cholesterol Gene VICE / CRISPR Can Now Edit Genes Using Nanoparticles Instead of Viruses Yahoo News / CNBC / Nanotech, gene editing used to edit cholesterol gene-US study/ Genetic Engineering & Biotechnology News / CRISPR/Cas9 Delivery Goes Nano with Enhanced Guide RNA Fiercebiotech / MIT scientists propose a safer way to edit genes with CRISPR / MIT News / Science Daily / Bioscience Technology / Medical News Today/Business Insider UK / The Medical News / Phys.org.

F1000 推荐

17. Yin H, Kauffman KJ and Anderson DG. Delivery technologies for genome editing. Nature Reviews Drug Discovery 2017, 16(6): 387-399.

18. Yin H, Song CQ, Dorkin JR, Zhu L, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi M, Walsh S, Bogorad R, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe S, Langer R, Xue W and Anderson DG. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nature Biotechnology 2016,34(3):328-33.

*媒体报道：Featured by MIT News / Science Daily / Bioscience Technology / Medical News Today / Deutsches Ärzteblatt / Nanowerk / Nanotechnology Now /The Medical News / Phys.org

19. Yin H^#, Bogorad RL^#, Barnes C, Walsh S, Zhuang I, Nonaka H, Ruda V, Kuchimanchi S, Nechev L, Akinc A, Xue W, Zerial M, Langer R, Anderson DG, Koteliansky V. RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver. Journal of Hepatology 2016, 64(4):899-907.

20. Mou H, Kennedy Z, Anderson DG, Yin H*, and Xue W*, Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Medicine 2015, 7(1):53.

21. Yin H^#, Xue W^#, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG (2014) Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology 2014, 32(6):551-3.

*100 top stories of 2014 by Discover Magazine as “A Giant Step for Gene Surgery”

*Top Ten Genetics Stories for 2014: Incredible Achievements, by the DNA Exchange

*专文评述: Nature Medicine (CRISPR technology for gene therapy) | 封面故事Science–Business eXchange of Nature Publishing Group | BioTechniques

*媒体报道：Featured by MIT News /英国独立报头版报道/ Fox News / The Times of India / Science Daily / Medical daily / The Voice of Russia / Phys.org /

F1000 推荐

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文选集

22. Xue W^#, Chen S^#, Yin H^#, Tammela T, Joshi N, Papagiannakopoulos T, Cai W, Yang G, Bronson R, Crowley D, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 2014, 514(7522):380-4.

*专文评述: Hepatology (Cutting short the path to murine liver cancer models)

*媒体报道: Featured by MIT News / Science Daily / Medical Press / Newswise / F1000Prime Recommendation.

23. Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nature Reviews Genetics 2014, 15(8):541-55.

24. Bogorad RL^#, Yin H^#, Zeigerer A, Nonaka H, Ruda VM, Zerial M, Anderson DG, Koteliansky V Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Nature Communications 2014, 5:3869.

*专文评述: Nature Reviews Gastroenterology & Hepatology (Loss of integrin β1 impairs liver regeneration and HCC progression)

25. Yin H, Cheng L, Holt M, Hail N, Jr., Maclaren R, Ju C, “Lactoferrin protects against acetaminophen-induced liver injury in mice”, Hepatology 2010, doi: 10.1002/hep.23476.

26. Yin H, Cheng L, Langenbach R, Ju C, “Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury”, Hepatology 2007, doi: 10.1002/hep.21493.