学习经历

1995-1999 武汉大学，学士

1999-2007 美国伊利诺大学香槟分校，博士

工作经历与任职

2007-2011 美国罗切斯特大学，博士后研究员

2011-2018 美国布兰迪斯大学，博士后研究员

2018-至今 武汉大学医学研究院，教授

研究方向

本实验室是一个跨学科的研究实验室，以探讨神经科学、寿命生物学及疾病模型研究领域的深入问题。实验室团队矢志不渝地深耕于微观世界，以模式生物秀丽隐杆线虫为研究载体，全方位揭示其神经系统的构造、感知反应和行为调控背后的分子机制。通过结合线虫和细胞系实验平台，研究遗传、表观遗传以及环境因素如何交织作用于生命时钟，进而影响个体的寿命长短和衰老进程；发掘线虫模型在阐释神经系统疾病发病机制、机体对环境刺激响应的规律；力求为改善人类生活质量、延长健康寿命提供更为科学的理论依据和转化应用前景。

获奖与荣誉

QNQR（2017）

代表性论文

1. Xue W, Chen Y, Lei Z, Wang Y, Liu J, Wen X, Xu F, Chen P, Wu Z, Jin YN*, Yu YV*.  Calcium levels in ASER neurons determine behavioral valence by engaging distinct neuronal circuits in C. elegans. Nat Commun. (2025) 16(1):1814

2. Xue W, Lei Z, Liu B, Guo H, Yan W, Jin YN, Yu YV.  Olfactory dysfunction as an early pathogenic indicator in C. elegans models of Alzheimer's and polyglutamine diseases. Front Aging Neurosci. (2024) 16:1462238.

3. Li X, Yu L, Liu X, Shi T, Zhang Y, Xiao Y, Wang C, Song L, Li N, Liu X, Chen Y, Petersen RB, Cheng X, Xue W, Yu YV, Xu L, Zheng L, Chen H, Huang K.  β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein. Nat Commun. (2024) 15(1):8748.

4. Yu YV, Xue W, Chen Y.  Multisensory Integration in Caenorhabditis elegans in Comparison to Mammals. Brain Sci. (2022) 12(10):1368.

5. Takeishi1 A*, Yu YV*, Hapiak VM, Bell HW, O’Leary T, Sengupta P.  Receptor-type guanylyl cyclases are thermosensory proteins in C. elegans. Neuron. (2016) 90:235

6. Yu YV, Bell HW, Glauser DA, Van Hooser SD, Goodman MB, Sengupta P.  CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron. Neuron. (2014) 84: 919

7. Gaspar I*, Yu YV*, Cotton SL, Kim DH, Ephrussi A, Welte MA.  Klar ensures thermal robustness of oskar localization by restraining RNP motility. J Cell Biol. (2014) 206:199

8. Wang TA*, Yu YV*, Govindaiah G, Ye X, Artinian L, Coleman TP, Sweedler JV, Cox CL, Gillette MU.  Circadian rhythm of redox state regulates excitability in suprachiasmatic nucleus neurons. Science. (2012) 337:839

9. Yu YV, Li ZH, Rizzo NP, Einstein J, Welte MA.  Targeting the Motor Regulator Klar to Lipid Droplets. BMC Cell Biol. (2011) 12:9