FEBS Lett.2017 Aug 17. doi: 10.1002/1873-3468.12796. [Epub ahead of print]

Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses.

Luo WW¹,Shu HB².

Author information

1 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

2 Medical Research Institute, School of Medicine, Wuhan University, China.

Abstract

Rhomboid-like pseudoproteases are a conserved superfamily of proteins related to the rhomboid intramembrane serine proteases that lack key catalytic residues. iRhom2, a member of the rhomboid-like pseudoprotease superfamily, regulates the maturation and trafficking of ADAM17 and is associated with inflammatory arthritis. Recent studies demonstrate that iRhom2 is also involved in innate immunity by regulating the trafficking and stability of MITA (also called STING), which is a central adaptor in innate antiviral signalling pathways. Here, we summarize recent progress on the roles and mechanisms of iRhom2 and its homologues in innate immunity and also discuss the links between the physiological functions of iRhoms and immunological diseases.

© 2017 Federation of European Biochemical Societies.

KEYWORDS:

inflammatory responses; innate immunity; rhomboid-like pseudoprotease