学习经历

2001 - 2005 上海交通大学，生物技术，学士

2005 - 2011 北京大学，生物技术专业，博士

工作经历与任职

2011 – 2015 北京大学BIOPIC，博士后

2012 – 2012 美国哈佛大学化学与化学生物系，访问学者

2015 – 2018 北京大学BIOPIC，助理研究员

2019 – 现在 武汉大学医学研究院/免疫与代谢前沿科学中心，教授

2019 – 现在 武汉大学口腔医院，兼聘教授

研究方向

细菌耐药，细菌感染与免疫

获奖与荣誉

中组部青年拔尖（2021）

湖北省楚天学者特聘教授 （2021）

湖北省杰出青年项目 （2022）

代表性论文

1. Zhou, Y., Liao, H., Pei, L., and Pu, Y* (2023). Combatting persister cells: The daunting task in post-antibiotics era. Cell Insight 2, 100104. 10.1016/j.cellin.2023.100104.

2. Zhang P^#, Qiu Y^#, Wang Y^#, Xiao Y, Yu S, Shi M, Ni Y, Miron R J, Pu Y*, Zhang Y* (2022) Nanoparticles Promote Bacterial Antibiotic Tolerance via Inducing Hyperosmotic Stress Response，Small, https://doi.org/10.1002/smll.202105525

3. Qiu Y^#, Yu S^#, Wang Y^#, Xiao L, Pei L, Pu Y*, Zhang Y*. (2022) Photothermal Therapy may be a Double-edge Sword by Inducing the Formation of Bacterial Antibiotic Tolerance. Biomaterials Science, 00，1-11.

4. Liu Z^#, Wang A^#, Pu Y^#, Li Z, Xue D, Zhang C, Xiang X, E J, Bu Z, Bai F & Ji J. (2021) Genomic and Transcriptomic Profiling of Hepatoid Adenocarcinoma of the Stomach. Oncogene, 40, 5705–5717.

5. Tong, Y.^{*, #} , Zhang, J.^#, Sun, N. ^#, Wang, X. ^#, Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., Pei, G., Song, F., Zhu, G., Wang, X., Xia, X., Chen, X., Jiang, L., Zhang, J., Ouyang, L., Zhang, B., Jiang, Y., Liu, X., Calderone, R., Bai, F.*, Zhang, L.*, Alterovitz, G. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 66, 1895-1905. (2021).

6. Mancini L, Terradot G, Tian T, Pu Y, Li Y, Lo C, Bai F and Pilizota T. (2020) A General Workflow for Characterization of Nernstian Dyes and Their Effects on Bacterial Physiology. Biophysical Journal, 117, 4–14.

7. Pu Y, Li Y, Bai F, et al. (2019). ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance. Molecular Cell, 73(1):143-156.

8. Pu Y, Ke Y, Bai F. (2017). Active efflux in dormant bacterial cells - New insights into antibiotic persistence. Drug Resist Updat 30, 7-14.

9. Jin L, Qin Q, Wang Y, Pu Y, Li Y, et al. (2017). Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development. PLoS Pathogens 12(9):e1005847.

10. Pu Y, Zhao Z, Li Y, Bai F, Xie X, et al. (2016). Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells. Molecular Cell, 62, 284-294. (Highlighted by Nature https://www.nature.com/articles/nature18442 and Nature Review Microbiology https://www.nature.com/articles/nrmicro.2016.72)

11. Guo X, Jin X, Lv X, Pu Y, Bai F*. (2015) Real Time Visualization of Perylene Nano-clusters (PNCs) in Water and Their Partitioning to Graphene Surface and Macrophage Cells. Environmental Science & Technology, 49 (13): 7926-7933.

12. Liu Y, Yang J, Zhao Z, Pu Y*, Bai F*. (2014) Bacterial Persistence. Science China Chemistry, 57 (12): 1625-1633

13. Pu Y, Kikuchi A, Moriyasu Y, Tomara M, Jin Y, Suga H, Wei T, Li Y, Omura T. (2011) Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects -implications for the virus origin. Journal of Virology, 85 (6): 2975-2979.

14. Akita F, Higashiura A, Shimizi T, Pu Y, Suzuki M, Ichiki T, Sasaya T, Kanamaru S, Arisaka F, Tsukihara T, Nakagawa A, Omura T. (2012) Crystal Structure and Octamerization of the Viroplasm Matrix Protein P9-1 of Rice Black Streaked Dwarf Virus. Journal of Virology, 86 (2): 746-756.

15. Zhou F, Pu Y, Wei T, Liu H, Deng W, Wei CH, Ding B, Omura T, Li Y. (2007). The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusionin insect host cells. Proceedings of the National Academy of Sciences USA. 104(49): 19547-19552.

16. Zhou F, Wu G, Deng W, Pu Y, Wei C, Li Y. (2007). Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8. Febs Letters 581(1): 34-40.