Stabilization of Notch1 by the Hsp90 Chaperon is Crucial for T Cell Leukemogenesis

DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia.

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia.

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival.

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.

MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene.