教育经历

2005-2009 吉林大学动物科技学院 动物科学 学士

2009-2014 中国农业大学生物学院 微生物与免疫学 博士

工作经历

2014.9-2019.9 美国北卡罗莱纳大学教堂山分校 博士后

2019.9-2021.2 美国北卡罗莱纳大学教堂山分校 助理研究员

2021.3-至今 武汉大学医学研究院/免疫与代谢前沿科学中心 教授

2022.1-至今 武汉大学中南医院医学研究院 教授

项目资助

武汉大学人才启动经费（2021-2024）

国家海外高层次人才项目（2022-2025）

国家自然科学基金面上项目（2021-2024， 2024-2028）

国家重点研发计划专项（2021-2024）

湖北省“武汉英才”创新人才项目（2022-2024）

获奖情况

1 Dupont First Prize of Scholarship Award, Dupont Company, 2013.

2 Excellent Scientific Reward by China Agricultural University, 2012-2013.

3 武汉英才-创新人才, 2021

4 湖北省百人计划（创新人才）, 2021

杂志审稿人

Cell insight, Autoimmunity , Journal of Clinical Immunology, Molecular Immunology, BMC Immunology

学术兼职

2021 – 至今 Associate Editor, Autoimmunity.

2022- Handling editor of Frontier immunology, Cancer Immunity and Immunotherapy special issue

研究领域

本课题组致力于免疫学尤其是T细胞免疫研究，阐明免疫细胞的命运决定机制。

T细胞在自身免疫疾病发病和抗病毒感染应答中具有重要作用。免疫系统的发挥正常功能有赖于效应T细胞和调节性T细胞分化和功能的稳态平衡。其运作不正常时，可导致多种免疫和代谢综合征。本课题组主要围绕生理和病理条件下T细胞各亚群免疫应答和致病机制调控进行研究。我们采用多种分子生化、组学和疾病动物模型等技术手段，期望揭示参与调控T细胞免疫反应的关键分子及其免疫调节机制，以期帮助设计干预T细胞应答的免疫治疗新策略。

代表性论文

1. Huiru Jing#, Jiayu Song#, Jie Sun , Shaojun Su, Jin Hu, Haojian Zhang, Yanmin Bi, Bing Wu*. (2024) METTL3 governs thymocyte development and thymic involution by regulating ferroptosis, Nature Aging. (*Corresponding author, accepted)

2. Kiapour N, ^# Wu B^#, Yan Wang…Wan YY, Markovic-Plese S (2022). Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells. Journal of Immunology. 209: 1-8. (^#co-first author)

3. Wu, B., Zhang S., Guo Z., Bi Y., Zhou M., Li P., Seyedsadr M., Xu X., Li J., Markovic-Plese S., Wan YY (2021). The TGF-b superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 54, 308-323 e306.

4. Wu, B^#., Zhang G^#., Guo Z., Wang G., Xu X., …Zheng J., Wan YY. 2020. The SKI proto-oncogene restrains the resident CD103+CD8+ T cell response in viral clearance. Cellular and Molecular Immunology 18, 2410–2421 (2021) (^#co-first author)

5. Wu B*., Wan Y*. (2020) Molecular control of pathogenic Th17 cells in autoimmune diseases. International Immunopharmacology. 80:106187. (*Co-corresponding author)

6. Wu, B., Zhang, S., Guo, Z., Wang, G., Zhang, G., Xie, L., Lou, J., Chen, X., Wu, D., Bergmeier, W., Zheng J., Wan YY. (2018). RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs. Immunity. 49, 886-898 e885.

7. Wu B^#, Wang Y^#, Wang C, Wang GG, Wu J, Wan YY. 2016. BPTF Is Essential for T Cell Homeostasis and Function. Journal of Immunology 197:4325-4333. (^#co-first author)

8. Wu B, Geng S, Bi Y, Liu H, Hu Y, Li X, Zhang Y, Zhou X, Zheng G, He B, Wang B. 2015. Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1. Clinical and Vaccine Immunology: CVI 22:883-895.

9. Wu B, Zou Q, Hu Y, Wang B. 2013. Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice. Human Vaccines & Immunotherapeutics 9:2133-2141.

10. Guo, Z., Wang, G., Wu, B., Chou, W.C., Cheng, L., Zhou, C., Lou, J., Wu, D., Su, L., Zheng, J., et al. (2020). DCAF1 regulates Treg senescence via the ROS axis during immunological ageing. The Journal of clinical investigation. Journal of Clinical Investigation. 130(11):5893–5908.

11. Yu W, Geng S, Suo Y, Wei X, Cai Q, Wu B, Zhou X, Shi Y, Wang B. 2018. Critical role of regulatory T cells in the latency and stress-induced reactivation of HSV-1. Cell reports 25 (9), 2379-2389. e3

12. Zhang, S., Takaku, M., Zou, L., Gu, A.D., Chou, W.C., Zhang, G., Wu, B., Kong, Q., Thomas, S.Y., Serody, J.S., et al. (2017). Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature 551, 105-109.

13. Zou Q, Wu B, Xue J, Fan X, Feng C, Geng S, Wang M, Wang B. 2014. CD8⁺ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. European Journal of Immunology 44:103-114.