教育经历

1998-2002 山东大学生命科学学院， 学士

2002-2008 北京大学生命科学学院， 博士

工作经历与任职

2008-2010 北京大学生命科学学院， 博士后

2010-2015 美国密西根大学医学院， 博士后

2015-2016 美国希望之城贝克曼研究所，博士后

2016-至今 武汉大学医学研究院， 教授

研究方向：

多种物理或化学因素能够引起细胞DNA的损伤和基因组不稳定。如果DNA损伤不能及时修复，细胞基因组可能发生基因突变，细胞周期可能发生紊乱，最终引起癌症发生等恶性结果。因此，如何正确完成DNA的损伤修复并维持基因组的稳定性，对于细胞的存活以及防止癌症等重大疾病的发生至关重要。我们实验室主要以与DNA损伤修复相关的分子机制研究为核心内容，希望研究结果对于肿瘤的诊断、抗肿瘤药物的设计等提供新的理论指导。

代表性论文：

1. Zhang X, Guo J, Shi X, Zhou X, Chen Q*. LUC7L3 is a downstream factor of SRSF1 and prevents genomic instability. Cell Insight. Online

2. Peng Q, Shi X, Li D, Guo J, Zhang X, Zhang X, Chen Q*. SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability. Cell Death Differ 2023 Jul;30(7):1849-1867.

3. Zhang W, Guo J, Chen Q*. Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus. Viruses 2022, 14(9), 2049.

4. Zhao Y, Yue S, Zhou X, Guo J, Ma S, Chen Q*. O-GlcNAc transferase promotes the nuclear localization of the focal adhesion-associated protein Zyxin to regulate UV-induced cell death. J Biol Chem. 2022 Apr;298(4):101776.

5. Li, D., Liu, X. & Chen, Q*. Centrosome, microtubule and DNA damage response. GENOME INSTAB. DIS. 3, 163–171 (2022).

6. Xu Z, Zhao L, Zhong Y, Zhu C, Zhao K, Teng Y, Cheng X, Chen Q, Xia Y. A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA. Cell Mol Gastroenterol Hepatol. 2022;13(4):1001-1017.

7. Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q*. DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair. J Cell Biol. 2021 Feb 1;220(2):e201911025.

8. Zhong L, Hu MM, Bian LJ, Liu Y, Chen Q, Shu HB. Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discov. 2020 Apr 28;6:26.

9. Li W, Wang HY, Zhao X, Duan H, Cheng B, Liu Y, Zhao M, Shu W, Mei Y, Wen Z, Tang M, Guo L, Li G, Chen Q, Liu X, Du HN. A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair. Sci Adv. 2019 Mar 6;5(3):eaau7566.

10. Chen, Q. and Yu, X. (2016) OGT restrains the expansion of DNA damage signaling. Nucleic acids research.

11. Zhuo, X., Guo, X., Zhang, X., Jing, G., Wang, Y., Chen, Q., Jiang, Q., Liu, J. and Zhang, C. (2015) Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. The Journal of cell biology, 210, 727-735.

12. Bian, C.#, Chen, Q.# and Yu, X. (2015) The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression. eLife, 4.

13. Wang, G.#, Chen, Q.#, Zhang, X., Zhang, B., Zhuo, X., Liu, J., Jiang, Q. and Zhang, C. (2013) PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. Journal of cell science, 126, 1355-1365.

14. Chen, Q., Chen, Y., Bian, C., Fujiki, R. and Yu, X. (2013) TET2 promotes histone O-GlcNAcylation during gene transcription. Nature, 493, 561-564.

15. Zhang, X., Chen, Q., Feng, J., Hou, J., Yang, F., Liu, J., Jiang, Q. and Zhang, C. (2009) Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. Journal of cell science, 122, 2240-2251.

16. Chen, Q., Zhang, X., Jiang, Q., Clarke, P.R. and Zhang, C. (2008) Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis. Cell research, 18, 268-280.