学习经历

2011-2015 北京大学生命科学学院，学士

2015-2020 英国牛津大学Nuffield Department of Medicine，博士

工作经历与任职

2020-2020 英国牛津大学Nuffield Department of Women's & Reproductive Health，博士后

2021-2023 英国牛津大学MRC Weatherall Institute of Molecular Medicine，博士后

2023至今 武汉大学医学研究院，教授

研究方向

胚胎发育和癌症有着密不可分的联系。癌症的表型和表观遗传特征往往重现了胚胎期的器官发育过程，癌症的发生发展亦会劫持胚胎发育期的调控机制。我们课题组的工作涵盖“湿实验-干实验”两方面，主要应用前沿单细胞多组学测序技术和生物信息学方法，以基因调控复杂网络为着手点，全面系统地去研究发育、癌症的单细胞基因调控网络，以及两者之间的联系。我们课题组的工作旨在全基因组层面、单细胞分辨率揭示癌症发生发展的机制，以推动癌症精准化分层和个性化治疗，为癌症的治疗方案开发研发新的靶点。

课题组热忱欢迎有兴趣的科研助理、学生和博士后加入我们的团队！

获奖与荣誉

2022 Junior Research Fellowship, Wolfson College, University of Oxford

2021 NIHR Oxford Biomedical Research Centre Small Grants in Health Sciences

2020 WHG Public Engagement Seed Award, University of Oxford

2019 AACR-Margaret Foti Scholar-in-Training Award, American Association for Cancer Research

代表性论文

1. Z. Hu, A. Ahmed*, C. Yau*. CIDER: an interpretable meta-clustering framework for single-cell RNA- seq data integration and evaluation. Genome Biology 22, 337 (2021).

2. Z. Hu†, P. Cunnea†, Z. Zhong, H. Lu, O. Osagie, L. Campo, M. Artibani, K. Nixon, J. Ploski, L. Santana Gonzalez, A. Alsaadi, N. Wietek, S. Damato, S. Dhar, S. P. Blagden, C. Yau, J. Hester, A. Albukhari, E. O. Aboagye, C. Fotopoulou*, A. A. Ahmed*. The Oxford Classic links epithelial-mesenchymal transition to immunosuppression in poor prognosis ovarian cancers. Clinical Cancer Research (2021).

3. Y. Liu^†, Z. Hu^†, J. Cheng, P. Siejka-Zielinska, J. Chen, M. Inoue, A. A. Ahmed, C.-X. Song. Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution. Nature Communications 12, 618 (2021).

4.Z. Hu, M. Artibani, A. Alsaadi, N. Wietek, M. Morotti, T. Shi, Z. Zhong, L. Santana Gonzalez, S. El- Sahhar, M. KaramiNejadRanjbar, G. Mallett, Y. Feng, K. Masuda, Y. Zheng, K. Chong, S. Damato, S. Dhar, L. Campo, R. Garruto Campanile, V. Rai, D. Maldonado-Perez, S. Jones, V. Cerundolo, T. Sauka-Spengler, C. Yau*, A. A. Ahmed*. The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells. Cancer Cell 37(2), 226–242.e7 (2020).

5. Z. Hu, C. Yau* and A. Ahmed*. A pan-cancer genome-wide analysis reveals tumour dependencies by induction of non-sense mediated decay. Nature Communications 8, 15943 (2017).

^† 共同第一作者；* 共同通讯作者。