学习经历

2001-2005 武汉大学生命科学学院 学士

2005-2010 武汉大学生命科学学院 博士

工作经历与任职

2010 - 2016 武汉大学生命科学学院 讲师、副教授

2016 - 2019 武汉大学医学研究院 副教授、副院长

2019 - 武汉大学医学研究院 教授、博导、副院长

获奖及荣誉

武汉大学自然科学研究优秀科技管理工作者（2018）

朱裕璧医学奖（2018）

教育部自然科学奖一等奖（第六完成人，2014）

武汉大学生命科学学院“我心中的优秀班级导师”（2014, 2016）

获得研究资助

1. 蛋白质翻译后修饰调控免疫应答信号跨膜传递的分子机制，国家重点研发计划青年科学家项目，主持，2022-2026；

2. IL-6受体泛素化调控机制，国家自然科学基金委面上项目，主持，2021-2024；

3. 酪氨酸蛋白激酶CSK在抗DNA病毒天然免疫中的功能和分子机制，国家自然科学基金委面上项目，主持，2019-2022；

4. 菱形蛋白酶iRhom2在抗DNA病毒天然免疫信号转导和炎症反应中的功能与机制研究，国家自然科学基金委面上项目，主持，2017-2020；

5. RHBDF2在细胞抗病毒反应中的作用及调节机制，国家自然科学基金青年项目，主持，2012-2014；

代表性论文

1. Liu R, Zeng LW, Li HF, Shi JG, Zhong B, Shu HB*, Li S* (2023). PD-1 signal negatively regulates the common cytokine receptor g chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity. Cell Res. 33(12):923-939.

2. Zeng LW, Feng L, Liu R, Lin H, Shu HB, Li S*(2022). The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Cell Mol Immunol. 19(10):1117-1129.

3. Yi XM, Li M, Chen YD, Shu HB, Li S*(2022). Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38, Proc. Natl. Acad. Sci. USA., 2022, 119(10): e2116279119

4. Feng L, Li C, Zeng LW, Gao D, Sun YH, Zhong L, Lin H, Shu HB, Li S* (2022). MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3R alpha. Signal Transduct Target Ther. 7(1):21.

5. Lin H, Feng L, Cui KS, Gao D, Zhang LX, Xu WH, Zeng LW, Sun YH, Shu HB*, Li S* (2021). The membrane-associated E3 ubiquitin ligase MARCH3 down-regulates IL-6 receptor and suppresses colitis-associated carcinogenesis. Cell Mol Immunol. 18(12):2648-2659.

6. Liu R, Zeng LW, Gong R, Yuan F, Shu HB, Li S*(2021). mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nat Commun.12(1):4227.

7. Cao P, Luo WW, Li C, Tong Z, Zheng ZQ, Zhou L, Xiong Y, Li S*. (2019) The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathog. 15(8):e1007983.

8. Wei J, Lian H, Guo W, Chen YD, Zhang XN, Zang R, Zhong L, Yang Q, Hu MM, Luo WW, Shu HB, Li S* (2018). SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA. Plos Pathogens. 14(10):e1007336

9. Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S*, Shu HB* (2018) . ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nat Commun. 9(1):3349.

10. Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S*, Shu HB* (2018). The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity. 18;49(3):438-448.

11. Liu Y, Zhou Q, Zhong L, Lin H, Hu MM, Zhou Y*, Shu HB*, Li S*(2018). ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. Cell Mol Immunol. doi: 10.1038/cmi.2017.146.

12. Wei J, Guo W, Lian H, Yang Q, Lin H, Li S*, Shu HB*.(2017) SNX8 mediates IFNγ-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes. Proc. Natl. Acad. Sci. USA. 114(49):13000-13005.

13. Luo WW, Li S*, Li C, Zheng ZQ, Cao P, Tong Z, Lian H, Wang SY, Shu HB and Wang YY*(2017). iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA. PLoS Pathogens. 13(11):e1006693.

14. Luo WW, Lian H, Zhong B, Shu HB, Li S*(2016). Krüppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol. 13(1):65-72.

15. Zhang J, Hu MM, Shu HB, Li S. * Death-associated protein kinase 1 is an IRF3/7-interacting protein involved in cellular antiviral immune response. (2014) Cell Mol Immunol. 11, 245–252.